Take back your energy and focus
Our bodies require peak-functioning cells for optimum health and vitality. Yet, as soon as we turn 25, declining hormones and a decrease in the production of mitochondria causes vital cells to age, leading to tiredness and lack of concentration.
Ageing cells affect core processes such as energy production, which is the cause of that post-lunch energy crash. Those ageing cells affect metabolism, which depends on the production of NAD+ (Nicotinamide Adenine Dinucleotide), and can be blamed for how much harder it is to shift those excess pounds. NAD+ decline also impacts the longevity genes SIRTUINS which regulate DNA repair, which is why those post-workout recoveries are so much harder and late evenings become a thing of the past.
Why NAD+ Supplementation?
A lack of cellular energy leads to serious cardiovascular diseases, diabetes and neurodegeneration - as well as visible signs of ageing - as the cells struggle to keep up with internal demands to repair and finetune their functions. The world’s biggest killer diseases today are; neurodegeneration, cancer, diabetes, and cardiovascular disease. The top risk factor for all of those? The patient’s age. What changes in our bodies as we age? NAD+ levels. Which is why it’s essential we boost our NAD+ levels as we age.
The Scientific Background
Human clinical trials have shown the best way to top up NAD+ levels is supplementing with NAD+ boosters like NMN. NMN is a vitamin B3 derivative and a direct precursor to NAD+, meaning it converts into NAD+ in one quick step. NAD+ itself is just too large a molecule to be easily absorbed by our cells. NMN is rapidly metabolised and so is shown to boost NAD+ in human muscle and liver tissues.
Restore energy levels by supplementing with NMN
The high purity of NMN Bio Ltd’s NMN enables you to efficiently restore declining NAD+ levels, to repair energy and concentration levels and fight the signs of ageing.
We extensively 3rd party test our products at each batch, guaranteeing your NMN is of a pharmaceutical grade, with a purity of more than 99%, that is an allergen-free and vegan product. Providing this premium quality NMN ensures superior bioavailability to boost your NAD+ levels as effectively as possible, which leads to not only increased energy, but the benefits of a plethora of vital cellular functions – and can even add years to your life.
NMN human clinical trials
NMN has been proven safe in high dosages up to 1.2g a day in human clinical studies. Furthermore, multiple health benefits have been demonstrated in humans as well. A study in prediabetic, postmenopausal, obese or overweight women showed that after 10 weeks of NMN supplementation, the volunteers had increased insulin sensitivity. Same study showed that NMN supplementation was able to stimulate the collagen production pathway, suggesting the compound's role in healthy aging (and appearance of skin).
A study in elderly men over 65 showed that NMN supplementation protects against age-related muscle loss. Another study in healthy, adult volunteers of both sexes confirmed that NMN increases endurance, cardiovascular fitness and aerobic capacity in amateur runners. Moreover, a recent study in both humans and mice, demonstrated lengthening of telomeres in both humans and mice after NMN supplementation. Telomeres are the caps at the end of our chromosomes and are essential for cellular health and healthy aging. The longer they are, the more we live!
- Safety study in healthy Japanese men
- Efficacy study in prediabetic, post-menopausal, obese or overweight women, demonstrating increase in insulin sensitivity. Same study showed NMN is stimulating the collagen production pathway.
- Efficacy study in elderly men (over 65), showing protection against age-related muscle loss
- Efficacy study in healthy adults showing improved cardiovascular fitness, increased aerobic capacity and endurance in amateur runners
- Efficacy study in humans and mice showing lengthening of telomeres in a dose dependent manner after 30, 45 and 60 days
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You can always ask a question
Does NMN have any known side effects?
The first human safety trial of NMN in humans was published in 2019 and showed that a single dose of up to 500mg was tolerable.
Three major studies of NMN are also currently underway involving human subjects. The first is being carried out by the Washington School of Medicine in St. Louis, and the second by Keio University Medical School in Tokyo, in conjunction with Washington School of Medicine. The third and perhaps most important study is being carried out by Brigham and Women's hospital in Boston, under the watchful eyes of Harvard longevity scientists. The results of these trials should be published soon.
Why should I take NMN before breakfast?
It increases absorption.
How much NMN should I take?
If you're younger than 35, you can start with 250mg/day and after 1-2weeks increase to 500mg to see what feels better.If you're older than 35, start with 500mg/day, then increase to 1g to see what feels better.
Should I take one capsule in the morning and one in the afternoon?
No. Take your NMN in the morning to synchronize your NMN consumption with your Circardian rhythms.
Should I break down the capsule for better absorption?
Dr David Sinclair and our founder Dr Elena Seranova don't bother and just take the capsule. There are actually no studies showing that sublingual powder or powder intake results in better absorption than the capsule.
What can amplify the effect of NMN supplementation?
Along with your NMN, take one tablespoon of extra virgin olive oil in the morning. Oleic acid, one of the ingredients in olive oil, is also shown to activate the SIRTUINS, the so-called longevity genes.
In addition, by supplementing with TMG (Trimethylglycine), you increase the methyl groups available in the cell (which NMN utilises). Adding TMG to your NMN supplementation is an excellent way to boost NMN efficiency and ensure balanced homocysteine levels.