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Berberine 400mg with Milk Thistle

Third-party tested

Founded by Dr Elena Seranova

30-day guarantee

Purchase options
£30.00/ bottle

Free UK delivery

Berberine supports metabolic function, insulin sensitivity, and lipid balance, key factors in longevity and cellular energy.

Benefits:

  • Improves Insulin Sensitivity: Enhances blood glucose regulation and carbohydrate metabolism.

  • Supports Lipid Balance: Helps reduce LDL cholesterol and promotes cardiovascular health.

  • Boosts Metabolic Function: Encourages efficient fat metabolism and energy utilisation.

  • Activates Autophagy: Stimulates cellular renewal by activating AMPK, a key longevity pathway.

Ingredients:
Berberine HCL, Silymarin/Milk Thistle, Bulking agent (Microcrystalline Cellulose), Capsule shell (Vegetable Cellulose)

Vegan, Non-GMO, and Allergen-Free.
Free from gluten, soy, nuts, fish, shellfish, and dairy.
Third-party tested and packaged in a GMP-certified UK facility.
NMN Bio is founded by a scientist and committed to full transparency and quality.

Encourage Metabolic Well-being & Cholesterol Balance

As we age, our bodies don't digest carbohydrates as efficiently, which can make it more challenging to maintain a healthy weight. Our carefully crafted Berberine with Milk Thistle supplement is designed to support your metabolism and help manage the demands of daily life.

The addition of Milk Thistle to our Berberine is intentional and formulated specifically to boost the absorption of Berberine, making it a great addition to your wellness routine. With this combination, you can support your body’s natural processes, helping to maintain balanced blood sugar and cholesterol levels, whilst promoting overall well-being as you age. This supplement fosters a healthy, vibrant lifestyle, supporting long-term health goals.

Aiding Blood Sugar Balance

To support a healthy lifestyle, maintaining balanced blood sugar levels is crucial as we age. Throughout life, our bodies naturally change how they process nutrients, particularly carbohydrates. This can sometimes lead to challenges in maintaining consistent glucose levels after meals. These changes may affect insulin function, resulting in insulin resistance. Research suggests this could be associated with various health conditions over time, including pre-diabetes and diabetes. Many people are exploring natural supplements like Berberine, renowned for its efficacy in supporting the body over time.

Supporting Heart Health & Balanced Weight

Many people interested in supporting their wellness journey find Berberine intriguing for its reputation for maintaining healthy lipid and cholesterol levels. Some individuals consider it a key part of their approach to cardiovascular health as they age.

Even for those at a healthy weight, many people aim to optimise their body composition. Existing research has shown that Berberine may activate AMPK, a pathway known to play a role in cellular processes like autophagy, which is involved in recycling cellular “waste” and supporting longevity. AMPK is also considered to help with energy balance and aid in glucose level control which in turn would support weight management but also contribute to overall vitality.

Those following a ketogenic lifestyle may be interested in Berberine’s potential role in supporting metabolic processes, especially after meals that include carbohydrates like bread and pasta. The AMPK pathway plays a role in how the body manages energy, which could help with the transition back into ketosis. Additionally, as Berberine is often associated with metabolicbalance, it may be of interest to those looking to support their body's natural rhythms, including the transition into a fat-burning state. Many see Berberine’s influence as a gentle addition to their wellness routine, and at NMN Bio it will always be free from unnecessary additives or harsh chemicals.

Berberine: Recommended Daily Dosage

Take 1-2 capsules a day with your meal or straight after. If you are having a carbohydrate heavy meal such as pasta or pizza, we recommend taking 3 capsules. If you have any existing health conditions or are taking medication, including for the liver or kidneys, always consult with a healthcare professional before introducing new supplements into your routine.

Additional Product Information

Berberine, a naturally occurring plant compound derived from various herbs, has been valued for centuries and is often explored for its role in wellness and balance.

This product is manufactured in a GMP-certified facility and undergoes third-party testing for quality and safety. It is packaged and tested in the UK to the highest industry standards.

Please note, that this product is a food supplement and is not intended to diagnose, treat, cure, or prevent any disease.

Berberine + Milk Thistle Answers

FAQ

Explore the human research on Berberine and the studies behind this ingredient.

Berberine Human Clinical Trials

Maintaining a healthy body and healthy weight protects us from many illnesses. Managing blood sugar and ensuring you don’t develop insulin resistance is one of the most crucial things you can do for your longevity and increasing your healthspan (the amount of time you spend in good health over the course of your life). 

There are tens of human clinical studies looking into diabetic patients and prediabetics, and how they respond to Berberine supplementation. Overall, findings show that Berberine is significantly improving markers related to blood sugar control like HbA1c, fasting plasma glucose and 2-hour postprandial blood glucose amongst others. Over this meta-analysis of 46 studies, Berberine demonstrated strong evidence of improving glycemic control and overall health in thousands of participants. 

In a human study of 37 men and women with metabolic syndrome took 300 milligrams of Berberine, three times a day for three months.  The study concluded that they all lost an average of two inches off their waist and their BMIs went from the obese to the overweight category.

In a recent study (2020), 900 people in China between the ages of 18-75 had polyps removed during a colonoscopy.  They were randomly given either 300 milligrams of Berberine twice daily or a placebo. The participants were then followed up the first year and again, the second year. The study found that none of the participants developed colorectal cancer, however, the participants taking the Berberine had fewer recurrent polyps at 36%, compared to the placebo participants with 47%.

PubMed shows the number of papers published on Berberine each year. In 2020, an astonishing 630 papers were published! As time progresses, more and more people will be aware of the outstanding benefits of supplementing with Berberine.

References

Noncommunicable Diseases 

National Diabetes Statistics Report

Type 2 diabetes and quality of life

The metabolism of berberine and it’s contribution to the pharmacological effects 

Herbal Management of hepatocellular carcinoma  through cutting the pathways of the common risk factors

Blood sugar regulation as a key focus for cardiovascular health promotion and prevention : an umbrella review 

Extracting the benefits of berberine for colorectal cancer 

Lipid-lowering effect of berberine in human subjects and rats 

The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension

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Customer reviews

What customers notice.

Read reviews on Trustpilot

Easier to remain consistent with my eating routine

“I started taking this because I was struggling with sugar cravings, and didn’t want to go on GLP1s. After about 10 days, I noticed that I wasn’t craving a dessert post lunch. The difference has made it easier to remain consistent with my eating routine.”

Berberine + Milk Thistle

I take it with my meals

“I had used berberine before, but I liked that this formulation also included milk thistle. I take it with my meals, and the main difference I’ve noticed is that I don’t get upset stomach anymore.”

Berberine + Milk Thistle

It has complemented both

“This has not replaced eating well or exercising, but it has complemented both. Over about 3 weeks, I noticed a change in my appetite, like I am more in control. I would recommend tracking results rather than expecting an overnight transformation.”

Berberine + Milk Thistle

Easy to keep in my routine

“I was initially concerned that berberine might be difficult on my stomach. My experience has been great with this product! After adjusting for carb heavy meals, it became easy to keep in my routine.”

Berberine + Milk Thistle

Berberine + Milk Thistle Answers

FAQ

Explore the Berberine and Milk Thistle formula, including absorption, daily use and common safety questions.

Is your Berberine easily absorbed?

NMN Bio’s Berberine is thoughtfully formulated with Silymarin (Milk Thistle extract) to support bioavailability. Additionally, taking Berberine with or directly after a meal that includes healthy fats—such as cheese, yoghurt, or olive oil—may further support its absorption.

How much Berberine should I take?

Many people take 1-2 capsules daily, with or directly after meals. Berberine typically remains active in the body for just a few hours. Some individuals prefer one capsule twice a day, while others may want to take both capsules after their final meal, which is a practice believed to activate natural cellular processes such as autophagy.

Is Berberine safe?

Berberine has been proven safe in human clinical trials with dosages up to 1.5g a day for 6 months in human subjects. In some cases, Berberine may cause mild digestive discomfort.However, the addition of Milk Thistle in our formula is intended to help support digestive comfort and reduce the likelihood of any issues.

Is Berberine the same as Metformin? Should I stop my Metformin medication while taking Berberine?

Berberine is a food supplement, while Metformin is a regulated, FDA-approved medication commonly prescribed to manage Type II Diabetes. Both have been studied for their potential to support healthy blood sugar levels. As with any supplement, it’s always a good idea to consult with your doctor before introducing new supplements into your routine or adjusting any current medications
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DISCLAIMER

Our formulations are backed by scientific research conducted by Dr. Elena Seranova and other researchers. While these studies support the potential benefits of individual ingredients, the statements made on this website have not been evaluated by regulatory authorities such as the FSA, FDA, MHRA, EMA, or their equivalents in other jurisdictions. These products are not intended to diagnose, treat, cure, or prevent any disease.

All information provided is for general informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely solely on this content when making health-related decisions.

Consult your healthcare provider before beginning any new supplement regimen, especially if you are pregnant, nursing, taking medication, or have a known medical condition. Do not discontinue or alter any prescribed medication without first consulting a qualified medical professional.

Product claims and regulatory status may vary by country. It is the responsibility of the purchaser to ensure that use of these products is compliant with local laws and regulations.