THE FACTS

Why NAD+ Supplementation?

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The Scientific Background

NAD was discovered over a hundred years ago by scientists studying fermentation. Recently it has been hailed as a super-centenarian molecule. This is because its role in the biological process of ageing is being recognized.  NAD levels have been shown to decline during chronological ageing and this decline is both a consequence of the ageing process and also a contributor to the development of age-related cellular dysfunction.

NAD+ plays a vital role in cellular health, metabolic and neuro-protection plus circadian rhythms which can all contribute to greater longevity. This is the reasons why so many people are keen to boost their NAD+ levels.

A decrease in NAD+ can a lead to a number of harmful outcomes including:

·     Increased risk of sunburn and skin cancer

·     Cell suffocation (Hypoxia)

·     Accelerated cardiovascular disease

·     Decreased metabolism

·     Impaired brain function

What is Nicotinamide Mononucleotide (NMN)?

As our cells can’t absorb NAD+ directly we need to use a “precursor”, which is a molecule that converts into NAD+. One of the precursors for NAD+ is beta nicotinamide mononucleotide or NMN. NMN is a Vitamin B3 (niacin) derivative. Put simply, NMN increases NAD+, activates the longevity genes SIRTUINS and suppresses ageing.

NMN has gained a lot of attention recently,especially after the release of longevity scientist, David Sinclair’s book Lifespan. In his book, the scientist discusses his research examining NMN, particularly in mice.

Can I get NMN from food?

NMN can be found naturally in foods such as broccoli, cabbage, avocados and tomatoes. However, as the concentrations are less than 1 mg per kg of food you would need to consume about 1kg of broccoli to get about 1mg of NMN! Therefore, you need a supplement to get an optimum level of NMN.

12 months study in mice

INCREASED HEALTHSPAN IN MICE

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The biology of aging

Why NAD+ Boosters?

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References

1) The Role of NAD+ in Anti-Aging Therapies: https://biomedgrid.com/fulltext/volume6/the-role-of-nad-in-anti-aging-therapies.001080.php

2) Q&A: How Harvard's David Sinclair is Fighting Aging—and How You Can, Too: https://blog.insidetracker.com/david-sinclair-fighting-aging-lifespan

3) It takes two to tango: NAD+ and sirtuins in aging/longevity control: https://www.nature.com/articles/npjamd201617

4) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/

5) CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism: https://www.sciencedirect.com/science/article/pii/S1550413116302248