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Founded by Dr Elena Seranova
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NAD+ Brain is a nootropic blend formulated to enhance focus, mental clarity, and long-term cognitive health.
Benefits:
Focus & Clarity: Caffeine and L-Theanine improve alertness and concentration without jitters.
Mood Support: Choline and Inositol balance neurotransmitters for calm focus.
Cell Protection: Fisetin, Apigenin, and Vitamin C protect brain cells from oxidative stress.
Memory & Learning: Phosphatidylserine and L-Tyrosine support recall, learning, and cognitive flexibility.
Neural Plasticity: Fisetin promotes adaptability and new neural connections.
Ingredients:
Vitamin C (Ascorbic Acid), Vitamin B6 (Pyridoxine Hydrochloride), Pantothenic Acid (Calcium D-Pantothenate), Zinc (as Zinc Gluconate), Apigenin, Caffeine, Citicoline, Fisetin, Inositol, L-Theanine, L-Tyrosine, Phosphatidylserine, Microcrystalline Cellulose (Bulking agent), Bamboo Silica (Anti-caking agent), Vegetable Capsule Shell (Hydroxypropyl Methylcellulose).
Allergen information: contains soy (traces).
The soy comes from the lecithin carrier used for Phosphatidylserine. NAD+ Brain is not allergen-free. Do not take it if you have a soy allergy.
Vegan and Non-GMO.
Free from gluten, nuts, fish, shellfish, and dairy.
Third-party tested and packaged in a GMP-certified UK facility.
NMN Bio is founded by a scientist and committed to full transparency and quality.
Losing your train of thought. Searching for a familiar name. You notice when your brain isn’t keeping up with you. After the age of 30, our cognitive abilities like memory and concentration are in decline. 20% of people over the age of 60 will get Mild Cognitive Impairment (MCI), after decades of a noticeable decline in episodic memory, especially remembering specific details and events. This issue now accelerates with extended use of AI and social media.
We made a science-backed, brain health supplement formula that is designed to enhance both short term focus in 20 minutes, and support long term brain health. Meet NAD+ Brain, the original blend that was formulated by Dr Elena Seranova, born out of research at the University of Birmingham, UK.
With NAD+ Brain, you're not just keeping up; you're setting up the pace.
Prevention starts in your late 20s and 30s. The second best time to start caring about your brain health is now.
Prevalence estimates for mild cognitive impairment in adults over 65 range from roughly 10 to 20% across population studies.
Why it happens
NAD+ is the molecule your cells use to turn food into energy and to run repair, and a neuron is about the most energy-hungry cell you own. Take NAD+ away and it does not slow down gracefully. It fails.
In 2023 we published a paper in Cell Reports on what happens inside a human neuron when its housekeeping system stops working properly. Two families of enzymes, the sirtuins and the PARPs, hyperactivate and begin consuming NAD+ faster than the cell can replace it. The mitochondria lose their electrical charge. Energy production falters. The neuron dies. And when we raised NAD+ in those cells, their survival improved.
So the interesting question stopped being how much NAD+ the brain makes, and became how fast it is being consumed. That question is what this formula was built around.
Graphical abstract
Congxin Sun, Elena Seranova, Malkiel A. Cohen, …, Rudolf Jaenisch, Viktor I. Korolchuk, Sovan Sarkar
Sun C., Seranova E., Cohen M.A. et al. NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency. Cell Reports 42(5):112372, 2023.
Customer reviews
“The difference in my mental sharpness between before and after starting NAD+ Brain has been noticeable. After taking it consistently for 2 weeks, I noticed an increase in my productivity, like the baseline of focus is now elevated. Combining it with NMN has become an essential part of my morning routine.”
NAD+ Brain
“I’ve tried several nootropic formulas, but many relied on caffeine and simply made me feel overstimulated. NAD+ Brain felt different. The focus developed gradually over weeks, and I found myself drinking less coffee while still concentrating for longer.”
NAD+ Brain
“This was not an overnight jolt, which I actually appreciated. Around week 2, I realised I was getting through the afternoon focus block without the usual mental dip or distraction. The effect feels steady rather than artificial.”
NAD+ Brain
“My wife and I have been using NAD+ Brain for a few months now. She noticed how she doesn’t need to nap in the afternoon anymore, while I noticed more output in my accounting job, getting things done faster and not missing any deadlines, which is crucial in my line of work. It is unusual for us to agree on a supplement, but this has become part of both our routines.”
NAD+ Brain
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NAD+ Brain Formula: what is in every serving
Each serving size (2 capsules) contains:
| Ingredient | Per serving | Why it’s included | Your benefit |
|---|---|---|---|
| Apigenin | 50mg | Studied as an inhibitor of CD38, one of the enzymes that consumes NAD+. NAD+ drives cellular energy production, and without it your brain cells would be dead in 30 seconds. Levels fall with age, so slowing the drain is the whole point. | NAD+ preserved in the brain |
| Fisetin | 80mg | A flavonoid with neuroprotective properties, and one of the most researched natural senolytics, the class of compounds studied for helping the body clear senescent cells. | Neurons nurtured, cellular clean-up |
| Phosphatidylserine | 50mg | A phospholipid found in neuronal cell membranes, studied for memory and cognitive function. Carried on soy lecithin, which is where the soy traces come from. | Memory retention |
| Citicoline | 200mg | Metabolised to cytidine and choline, both of which cross the blood brain barrier. Feeds acetylcholine production and supports neuronal membranes. | Focus and mental processing |
| Caffeine | 50mg | 25mg per capsule, roughly a quarter of a coffee. Enough to lift alertness, not enough to build the dependency an afternoon espresso does. | Clean alertness, no spiral |
| L-Theanine | 100mg | From green tea. Encourages alpha wave activity, the relaxed and alert state. Here at twice the caffeine dose, which is the ratio the research uses. | Calm focus without the jitters |
| Vitamin C | 200mg | Contributes to normal psychological function and protects cells from oxidative stress. The brain uses more of it, proportionally, than most tissue. | Antioxidant defence |
| Inositol | 200mg | Involved in neurotransmitter signalling, and studied for its role in mood and cognitive balance. | Steadier mood |
| L-Tyrosine | 100mg | A precursor to dopamine and noradrenaline. Most studied for holding cognitive performance together under stress and sleep debt. | Resilience under pressure |
| Vitamin B6 and Vitamin B5 | 5mg | Cofactors in neurotransmitter synthesis and energy metabolism. Not decoration: the tyrosine and citicoline pathways need them to run. | Mental energy metabolism |
| Zinc | 2mg | Contributes to normal cognitive function and is involved in neural communication and memory formation. | Sharper memory |
Studied as an inhibitor of CD38, one of the enzymes that consumes NAD+. NAD+ drives cellular energy production, and without it your brain cells would be dead in 30 seconds. Levels fall with age, so slowing the drain is the whole point.
NAD+ preserved in the brain
A flavonoid with neuroprotective properties, and one of the most researched natural senolytics, the class of compounds studied for helping the body clear senescent cells.
Neurons nurtured, cellular clean-up
A phospholipid found in neuronal cell membranes, studied for memory and cognitive function. Carried on soy lecithin, which is where the soy traces come from.
Memory retention
Metabolised to cytidine and choline, both of which cross the blood brain barrier. Feeds acetylcholine production and supports neuronal membranes.
Focus and mental processing
25mg per capsule, roughly a quarter of a coffee. Enough to lift alertness, not enough to build the dependency an afternoon espresso does.
Clean alertness, no spiral
From green tea. Encourages alpha wave activity, the relaxed and alert state. Here at twice the caffeine dose, which is the ratio the research uses.
Calm focus without the jitters
Contributes to normal psychological function and protects cells from oxidative stress. The brain uses more of it, proportionally, than most tissue.
Antioxidant defence
Involved in neurotransmitter signalling, and studied for its role in mood and cognitive balance.
Steadier mood
A precursor to dopamine and noradrenaline. Most studied for holding cognitive performance together under stress and sleep debt.
Resilience under pressure
Cofactors in neurotransmitter synthesis and energy metabolism. Not decoration: the tyrosine and citicoline pathways need them to run.
Mental energy metabolism
Contributes to normal cognitive function and is involved in neural communication and memory formation.
Sharper memory
Per two capsule serving. The combination is our own proprietary formulation. The contents are not a secret.
Compare your options
Fast, or transparent, or built for the long run. Most nootropics pick one.
| Option | Felt the same day | Doses published | Long-arc mechanism |
|---|---|---|---|
| Typical proprietary blend | Yes, 45 to 90 minutes | No | No claim |
| Typical transparent nootropic | No, 4 to 6 weeks | Yes | No mechanism |
| Plain coffee | Yes, 20 to 45 minutes | Not applicable | No |
| NAD+ Brain | Yes, about 20 minutes | Yes, all twelve | Yes, and it is published research |
We are not claiming this is the strongest stimulant you can buy. It is not, and it is not trying to be. It is the only one we know where the same formula answers what you need this morning and what your brain needs to offset cognitive decline in the long term.
Practical guidance
the caffeine is low but it is not zero
either works
just count the total across the day if you are sensitive
NAD+ Brain Answers
Straight answers about NAD+ Brain, from ingredients and caffeine to timing and taking it alongside NMN.
Most people report feeling NAD+ Brain within about twenty minutes, which is faster than the 45 to 90 minutes usually reported for the better known nootropic blends. The acute ingredients are built for that: a low dose of caffeine paired with L-theanine, alongside citicoline and L-tyrosine, which feed the pathways behind acetylcholine and dopamine.
The longer arc, which is the reason the formula exists at all, builds over weeks.
Onset times are customer-reported and individual results vary.
25mg per capsule, which is less than half a cup of coffee. It is enough to lift alertness and it is paired with L-theanine so it arrives without the edge, but it is not enough to build the dependency a mid-afternoon double espresso does. If you are caffeine sensitive, this is usually the dose that works when coffee does not.
Take NAD+ Brain in the morning and it should not affect your sleep. At 25mg a capsule the caffeine content is low, and the L-theanine alongside it takes the edge off rather than adding to it. You can drink coffee as well, though if you are sensitive it is worth counting the total across the day. Avoid taking it late in the afternoon.
It is a proprietary, original blend. And every ingredient in NAD+ Brain is listed with its dose, so you can see exactly what you are taking and compare it against the research. A lot of proprietary blends are commonly not disclosing the dosages of their ingredients in the nootropic category; because they hide whether an ingredient is present in an amount that could do anything. We would rather be checked.
Citicoline is a compound the body uses in the production of acetylcholine, the neurotransmitter most associated with attention and memory formation, and in maintaining neuronal cell membranes. It is one of the more researched nootropic ingredients and it is included here at a disclosed dose rather than as a label decoration. It sits alongside phosphatidylserine and L-tyrosine in the formula.
The formula came out of our founder's own laboratory work on what happens to NAD+ inside brain cells. In a 2023 paper in Cell Reports, Dr Elena Seranova and colleagues showed that when a neuron's housekeeping system fails, two families of NAD-consuming enzymes, the sirtuins and the PARPs, hyperactivate and burn through the cell's NAD faster than it can be replaced, and that raising NAD improved the survival of those neurons. That finding is why this formula exists.
Reference: Sun C., Seranova E., Cohen M.A. et al., Cell Reports 42(5):112372, 2023.
Yes, in traces. The soy comes from the lecithin carrier used for phosphatidylserine, one of the active ingredients. NAD+ Brain is not allergen-free and should not be taken if you have a soy allergy. It is vegan and non-GMO, and free from gluten, nuts, fish, shellfish and dairy.
Yes, and many customers take both in the morning. They do different jobs. NMN is a direct NAD+ precursor working at the level of cellular energy across the body and boosts your NAD+. The NAD+ Brain is formulated to specifically preserve your NAD+ in the brain, combining same-day focus ingredients with compounds chosen for longer term cognitive support. The Morning Bundle pairs them with TMG.
Take it in the morning, following the dose on the label. Morning dosing matters here because of the caffeine content, low as it is, and because the focus benefit is most useful at the start of a working day. Do not take it late in the afternoon or in the evening.
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Our formulations are backed by scientific research conducted by Dr. Elena Seranova and other researchers. While these studies support the potential benefits of individual ingredients, the statements made on this website have not been evaluated by regulatory authorities such as the FSA, FDA, MHRA, EMA, or their equivalents in other jurisdictions. These products are not intended to diagnose, treat, cure, or prevent any disease.
All information provided is for general informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely solely on this content when making health-related decisions.
Consult your healthcare provider before beginning any new supplement regimen, especially if you are pregnant, nursing, taking medication, or have a known medical condition. Do not discontinue or alter any prescribed medication without first consulting a qualified medical professional.
Product claims and regulatory status may vary by country. It is the responsibility of the purchaser to ensure that use of these products is compliant with local laws and regulations.
