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Trimethylglycine (Betaine) supports methylation, a key biological process for DNA repair, detoxification, and heart health.
Benefits:
Complements NMN: Provides methyl groups required for NAD+ synthesis.
Heart & Liver Support: Aids healthy lipid metabolism and detoxification.
DNA Maintenance: Supports repair and cellular stability through methylation.
Balances Homocysteine: Helps maintain optimal cardiovascular and brain health.
Ingredients:
Trimethylglycine Anhydrous (Betaine), Microcrystalline Cellulose (Bulking agent), Vegetable Capsule Shell (Hydroxypropyl Methylcellulose), Bamboo Silica (Anti-caking agent).
Vegan, Non-GMO, and Allergen-Free.
Free from gluten, soy, nuts, fish, shellfish, and dairy.
Third-party tested and packaged in a GMP-certified UK facility.
NMN Bio is founded by a scientist and committed to full transparency and quality.
Betaine, also known as trimethylglycine (TMG), has been studied for its multiple benefits when it comes to cellular health. From supporting DNA repair, to heart health and focus benefits for those suffering from ADHD, TMG is has an array of benefits for human health. Frequently used with NMN, a common anti-aging supplement, TMG is also an excellent supplement to enhance heart and liver health. With regards to focus and concentration, TMG acts as a catalyst for better neuronal function, and hence provides noticeable results in terms of managing symptoms of Attention Deficit Hyperactivity Disorder (ADHD). TMG may help regulate levels of neurotransmitters such as dopamine, serotonin, and norepinephrine. These neurotransmitters are involved in mood regulation, attention, and focus, and imbalances in their levels have been associated with ADHD symptoms. TMG supplementation has been linked to reduced stress responses in some studies. Stress exacerbates ADHD symptoms in many individuals, so reducing stress levels could potentially help manage ADHD symptoms. Read more about the TMG benefits for ADHD HERE.
Aging is a big factor in our ability to maintain efficient methylation. As we get older our methylation ability declines and without adequate methylation our abilities to read and activate the correct parts of our DNA blueprints are hampered. Trimethylglycine (TMG) also called Betaine - is a naturally occurring substance in the body. It’s involved in liver function, cellular reproduction, and it helps make essential metabolic compounds.
TMG is a glycine molecule with 3 methyl groups attached to it, making it a supplement capable of supporting the vital process of methylation in the body. It also is proven to lower the levels of the harmful amino acid homocysteine, converting it into harmless methionine, according to multiple clinical studies. High levels of homocysteine are associated with cardiovascular and Alzheimer’s disease. Optimal levels of methylation are correlated with healthy liver and heart. TMG is an essential supplement that will nourish your cells and ensure your cellular maintenance is taken care of.
Research shows healthy methylation is important in keeping DNA healthy in every cell and organ of the body and by supporting healthy methylation TMG also helps facilitate DNA repair.
TMG can be taken with NMN (which utilises methyl groups) for optimal efficacy. TMG will provide the necessary methyl groups for NMN to be as efficient as possible.
Customer reviews
“I added TMG because I was already taking NMN and wanted a more complete protocol. After 2 weeks, I noticed about 20% more endurance at the gym. It is now something I take automatically alongside my morning NMN.”
TMG
“TMG is not the kind of supplement that produces a dramatic immediate sensation. For me, the difference has been in better digestion, so I take it with my meals. I value that it supports the rest of my routine without adding complexity.”
TMG
“I originally purchased TMG after reading about methylation support. What made me continue was an effect on focus and concentration. The capsules are easy to take and combine well with NMN.”
TMG
“I had been taking NMN on its own for about 2 years before adding TMG. After combining them, I noticed better sleep, especially if I switch the TMG to evening. It feels like a more considered approach than simply increasing my NMN dose.”
TMG
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TMG Answers
Common questions about TMG, including timing, daily use and taking it alongside NMN.
TMG is an excellent supplement for anyone over 25.
As our hormones and our NAD+ production peaks at this age, this is when the methylation starts being less and less efficient. TMG comes to the rescue, ensuring optimal DNA methylation (the housekeeping of your genes), preventing the toxic build up of the amino acid homocysteine and making sure your liver and heart maintain optimal function.
This depends on your age and your individual genetics. Usually people start with a 1:1 ration of NMN and TMG. To ensure optimal methylation (as NMN utilises methyl groups to work its magic in your body), you can eventually (in 3-6 weeks) increase the ratio to 1:2, meaning that for each 500mg of NMN, you would need 1g of TMG. If you are supplementing with NMN for a long time already, you can start with 1:2 ratio, and then increase the ratio to 1:3 (1g of NMN to be taken with 3g of TMG). This can be done after about a month on the 1:2 ratio.
You can take TMG either first thing in the morning along with your NMN, or right after breakfast with a glass of water
TMG has no major side effects for most people. However, it is worth noting that TMG is an osmoregulator. This means that it is a molecule that helps your cells staying hydrated.
In very high dosages(over 20g/day), this property can lead to a laxative effect, but this will not be the case if you stick to the recommended dosages of up to 3-4g a day.
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Our formulations are backed by scientific research conducted by Dr. Elena Seranova and other researchers. While these studies support the potential benefits of individual ingredients, the statements made on this website have not been evaluated by regulatory authorities such as the FSA, FDA, MHRA, EMA, or their equivalents in other jurisdictions. These products are not intended to diagnose, treat, cure, or prevent any disease.
All information provided is for general informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely solely on this content when making health-related decisions.
Consult your healthcare provider before beginning any new supplement regimen, especially if you are pregnant, nursing, taking medication, or have a known medical condition. Do not discontinue or alter any prescribed medication without first consulting a qualified medical professional.
Product claims and regulatory status may vary by country. It is the responsibility of the purchaser to ensure that use of these products is compliant with local laws and regulations.
