L-Theanine and Adderall: A Comprehensive Analysis

L-Theanine and Adderall: A Comprehensive Analysis

In recent years, the use of cognitive-enhancing supplements has surged, with individuals seeking to optimize their mental performance for various tasks. Among these supplements, L-Theanine and Adderall have gained attention for their purported cognitive benefits.

L-Theanine, an amino acid found in tea leaves, is known for its calming effects, while Adderall, a prescription stimulant, is commonly used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.

This article provides a comprehensive analysis of L-Theanine and Adderall, exploring their mechanisms of action, potential benefits, and side effects.

What is Adderall?

Adderall, a prescription medication, is a blend of two central nervous system stimulants: amphetamine and dextroamphetamine. It was discovered in the 1920s and later approved by the FDA in 1996 to manage symptoms of narcolepsy and ADHD.

The drug is available in two formulations: immediate-release (Adderall IR) and extended-release (Adderall XR), each with varying dose strengths. The IR version is available in seven dose strengths, ranging from 5 mg to 30 mg. The XR version, on the other hand, comes in six dose strengths, from 5 mg to 30 mg.

Benefits of Adderall

Adderall has been extensively studied for its effectiveness in managing the symptoms of ADHD. It improves cognitive function, academic performance, and productivity in individuals with ADHD, leading to better focus, organization, and task completion. It works by increasing the levels of dopamine and norepinephrine in the brain, which enhances focus, attention, and alertness.

It is also commonly prescribed for the treatment of narcolepsy, a chronic neurological disorder characterized by excessive daytime sleepiness, sudden muscle weakness, hallucinations, and sleep paralysis. By stimulating the release of dopamine and norepinephrine in the brain, Adderall helps individuals with narcolepsy stay awake and alert throughout the day, mitigating the debilitating effects of excessive daytime sleepiness.

Adderall has been used off-label as a cognitive enhancer by individuals seeking to enhance their mental performance, particularly in demanding academic or professional environments.

Potential Side Effects of Adderall

Adderall, while effective in managing ADHD and narcolepsy, is not without its potential side effects. Some users may experience:

  • Dizziness
  • Headaches
  • Nausea
  • Increased heart rate
  • High blood pressure
  • Sleep disturbances
  • Loss of appetite
  • Mood swings
  • Irritability

Alcohol must be limited when taking Adderall as when mixed with alcohol; the drug can lead to cardiovascular side effects like increased heart rate, chest pain, or blood pressure changes.

While Adderall is approved for use in both children and adults, it's not safe for individuals with certain underlying medical conditions such as cardiovascular disorders, hyperthyroidism, glaucoma, and severe anxiety or agitation. It's also important to note there's also a potential for dependency and withdrawal symptoms with prolonged use. It's essential to consult your doctor before starting treatment with this medication.

What is L-Theanine?

L-Theanine is a non-protein amino acid primarily found in tea leaves, particularly in green tea. It is known for its ability to promote relaxation without sedation, which is attributed to its effects on neurotransmitters in the brain.

It increases levels of gamma-aminobutyric acid (GABA), serotonin, and dopamine, which are associated with mood regulation and relaxation. Additionally, it can cross the blood-brain barrier and modulate alpha brain waves, leading to a state of calm alertness.

Benefits of L-Theanine

While Adderall is FDA-approved for ADHD treatment, it's not the only option. L-Theanine, though not FDA-approved for ADHD, has shown promising research in treating ADHD by improving focus, attention, and mental clarity.

For example, L-Theanine has been shown to enhance cognitive function by improving attention and focus through increasing levels of neurotransmitters such as dopamine and serotonin. This is particularly beneficial for those with ADHD who have difficulty concentrating as well as students, professionals, and anyone else who needs to stay focused for extended periods.

Another key benefit of L-Theanine is its potential to improve sleep quality. A study by Williams et al. (2016) found that doses of 250 mg and 400 mg of L-Theanine greatly improved sleep in animals and humans. They further discovered that 200 mg of L-Theanine reduced resting heart rate, indicating its ability to promote relaxation. These benefits make it a popular choice for those seeking to reduce anxiety and stress.

L-Theanine and Caffeine

L-Theanine and caffeine work in harmony to enhance cognitive function. While L-Theanine is known for its calming effects, promoting an alert yet relaxed state, without inducing drowsiness. Caffeine, on the other hand, is a potent stimulant that invigorates the nervous system, enhancing alertness and reducing the perception of effort.

When combined in a supplement, like NAD+ Brain, these two compounds synergize to optimize focus, attention, and mental endurance. This natural blend avoids the overstimulation or subsequent crash commonly associated with caffeine alone, making it a powerful yet gentle enhancer for overall brain health.

For example, Kahathuduwa et al. (2019) discovered that the combination of L-Theanine and caffeine improved sustained attention and overall cognitive performance in children with ADHD.

Potential Side Effects of L-Theanine

While L-Theanine is generally well-tolerated, it's not without potential side effects. Some users have reported experiencing:

  • Headaches
  • Dizziness
  • Upset stomach
  • Drop in blood pressure
  • Nausea

The effects of L-Theanine can vary from person to person. Factors such as age, sex, weight, and underlying health conditions can influence how an individual responds to the supplement. Therefore, it's always advisable to start with a low dose and monitor your symptoms.

It's also important to note that L-Theanine interacts with antidepressants and blood pressure medications. L-Theanine may potentiate the effects of anti-depressants, potentially leading to increased sedation or changes in mood. This interaction could be particularly relevant for antidepressants that affect serotonin levels, as L-Theanine has been shown to modulate serotonin receptors in the brain.

Similarly, L-Theanine may also interact with blood pressure medications, especially those that lower blood pressure by affecting neurotransmitters or vascular function. L-Theanine has been reported to have hypotensive effects, meaning it may reduce blood pressure. When taken concurrently with blood pressure medications, this could lead to an excessive drop in blood pressure, potentially causing dizziness, lightheadedness, or fainting.

L-Theanine and Caffeine vs Adderall: Which Solution is Right For You?

Choosing between L-Theanine and caffeine versus Adderall depends on individual needs, preferences, and health considerations. L-Theanine and caffeine offer a natural and milder alternative to Adderall, promoting alertness and focus without the potential risks and side effects associated with prescription stimulants.

L-Theanine, found in tea leaves, induces a state of relaxed alertness by modulating neurotransmitters in the brain, while caffeine enhances arousal and cognitive function. This combination is often sought after for its balanced and jitter-free energy boost.

Conversely, Adderall provides a potent and rapid improvement in focus and attention, making it suitable for individuals with diagnosed conditions like ADHD or narcolepsy. However, its use requires caution due to the risk of side effects and the potential for dependency.

In terms of affordability, L-Theanine and caffeine supplements typically offer better value. They're readily available (from NMN Bio) without a prescription at a fraction of the cost of the cost of Adderall.

Ultimately, the choice between L-Theanine and caffeine versus Adderall depends on individual circumstances, including health status, desired effects, and tolerance to stimulants, with consultation with your healthcare provider being advisable for personalized guidance.

Using Adderall and L-Theanine Together

Some individuals combine Adderall and L-Theanine to mitigate the adverse effects of Adderall while enhancing its cognitive benefits. Adderall increases the levels of dopamine and norepinephrine in the brain, improving focus, attention, and alertness. However, it may also cause side effects such as increased heart rate, insomnia, and anxiety in some users.

L-Theanine, on the other hand, promotes relaxation without sedation and modulates neurotransmitters like GABA, serotonin, and dopamine. L-Theanine may counteract the jitteriness and anxiety associated with Adderall use. Some individuals find that combining Adderall with L-Theanine provides a smoother and more balanced cognitive enhancement experience, with reduced feelings of agitation and improved focus.

When considering the combination of L-Theanine and Adderall, it's crucial to understand the potential interactions between these drugs. Interestingly, no direct interactions have been found between Adderall and L-Theanine. However, this doesn't necessarily mean that no interactions exist. It's always advisable to consult a healthcare professional before mixing any medications.

Bringing Our Comparison of L-Theanine and Caffeine vs Adderall to a Close

The comparison between L-Theanine and caffeine versus Adderall presents a nuanced understanding of cognitive enhancement options. While Adderall remains a potent prescription medication approved to treat ADHD and narcolepsy, its use comes with potential risks and side effects, particularly for individuals with certain underlying medical conditions.

On the other hand, L-Theanine and caffeine offer a natural alternative that promotes alertness, focus, and cognitive function without the same level of risk. The combination of L-Theanine and caffeine provides a balanced and jitter-free energy boost, while some individuals find that adding L-Theanine to their Adderall regimen helps to mitigate its side effects and enhance cognitive benefits.

Ultimately, the choice between these options depends on individual preferences, health considerations, and the guidance of healthcare professionals. By understanding the strengths and limitations of each approach, individuals can make informed decisions to optimize their cognitive performance while prioritizing their overall well-being.

NMN Bio's NAD+ Brain supplement offers a promising avenue to support brain health and optimize mental performance. The supplement, formulated with L-Theanine and other essential nutrients, aims to enhance focus and concentration and guard the brain from oxidative stress and inflammation. 

Researched and reviewed by Dr Elena Seranova, Ph.D.

Dr Seranova holds a master's degree in Translational Neuroscience from the University of Sheffield, UK, and a Ph.D in Stem Cell Biology and Autophagy from the University of Birmingham, UK. She is a published author in multiple peer-reviewed journals, including Cell Reports and Developmental Cell.


Drugs.com. Drug Interactions between Adderall and L-Theanine.

Faraone., S, & Biederman, J. Efficacy of Adderall for Attention-Deficit/Hyperactivity Disorder: a meta-analysis. Journal of Attention Disorders. (2002)

Higashiyama et al. Effects of L-Theanine on attention and reaction time response. Journal of Functional Foods. (2011)

Kahathuduwa et al. L-Theanine and Caffeine Improve Sustained Attention, Impulsivity and Cognition in Children with Attention Deficit Hyperactivity Disorders by Decreasing Mind Wandering. Current Developments in Nutrition. (2019)

Lakhan., S, & Kirchgessner, A. Prescription stimulants in individuals with and without attention deficit hyperactivity disorder: misuse, cognitive impact, and adverse effects. Brain and Behavior. (2012)

Williams et al. L-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion. Beverages. (2016)