• NMN and Quercetin Human Clinical Trials

  NMN has been proven safe in high dosages up to 1.2g a day in human clinical studies. Furthermore, multiple health benefits have been demonstrated in humans as well. A study in prediabetic, postmenopausal, obese, or overweight women showed that after 10 weeks of NMN supplementation, the volunteers had increased insulin sensitivity. Same study showed that NMN supplementation was able to stimulate the collagen production pathway, suggesting the compound's role in healthy aging (and appearance of skin). A study in elderly men over 65 showed that NMN supplementation protects against age-related muscle loss. Another study in healthy, adult volunteers of both sexes confirmed that NMN increases endurance, cardiovascular fitness and aerobic capacity in amateur runners. Moreover, a recent study in both humans and mice, demonstrated lengthening of telomeres in both humans and mice after NMN supplementation. Telomeres are the caps at the end of our chromosomes and are essential for cellular health and healthy aging. The longer they are, the more we live!

  Quercetin has been proven safe in high doses up 1000mg to in human clinical studies, with a high number of studies showing no or few adverse effects and/ or toxicity. In one study, 84 patients with idiopathic hypertension and gout took 1000mg quercetin twice a day for 6 months and then 500mg twice a day for another 6 months (12 months in total). Results showed improvement of cardiac diastolic function, purine metabolism, renal function and normalization of blood pressure. Another study saw 50 women with rheumatoid arthritis who took 500mg quercetin a day for 8 weeks display lower plasma levels and lessened pain.

   

  References

  Safety study in healthy Japanese men

  Efficacy study in prediabetic, post-menopausal, obese or overweight women, demonstrating increase in insulin sensitivity. Same study showed NMN is stimulating the collagen production pathway.

  Efficacy study in elderly men (over 65), showing protection against age-related muscle loss

  Efficacy study in healthy adults showing improved cardiovascular fitness, increased aerobic capacity and endurance in amateur runners

  Efficacy study in humans and mice showing lengthening of telomeres in a dose dependent manner after 30, 45 and 60 days

  Quercetin as an antiinflammatory analgesic.

  Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

  WHO - Cardiovascular diseases.

  Role of quercetin in cardiovascular diseases.

  Therapeutic potential of quercetin as a cardiovascular agent.

  Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application.

• Berberine Human Clinical Trials

  Maintaining a healthy body and healthy weight protects us from many illnesses. Managing blood sugar and ensuring you don’t develop insulin resistance is one of the most crucial things you can do for your longevity and increasing your healthspan (the amount of time you spend in good health over the course of your life). 

  There are tens of human clinical studies looking into diabetic patients and prediabetics, and how they respond to Berberine supplementation. Overall, findings show that Berberine is significantly improving markers related to blood sugar control like HbA1c, fasting plasma glucose and 2-hour postprandial blood glucose amongst others. Over this meta-analysis of 46 studies, Berberine demonstrated strong evidence of improving glycemic control and overall health in thousands of participants. 

  In a human study of 37 men and women with metabolic syndrome took 300 milligrams of Berberine, three times a day for three months.  The study concluded that they all lost an average of two inches off their waist and their BMIs went from the obese to the overweight category.

  In a recent study (2020), 900 people in China between the ages of 18-75 had polyps removed during a colonoscopy.  They were randomly given either 300 milligrams of Berberine twice daily or a placebo. The participants were then followed up the first year and again, the second year. The study found that none of the participants developed colorectal cancer, however, the participants taking the Berberine had fewer recurrent polyps at 36%, compared to the placebo participants with 47%.

  PubMed shows the number of papers published on Berberine each year. In 2020, an astonishing 630 papers were published! As time progresses, more and more people will be aware of the outstanding benefits of supplementing with Berberine.

  References

  Noncommunicable Diseases 

  National Diabetes Statistics Report

  Type 2 diabetes and quality of life

  The metabolism of berberine and it’s contribution to the pharmacological effects 

  Herbal Management of hepatocellular carcinoma  through cutting the pathways of the common risk factors

  Blood sugar regulation as a key focus for cardiovascular health promotion and prevention : an umbrella review 

  Extracting the benefits of berberine for colorectal cancer 

  Lipid-lowering effect of berberine in human subjects and rats 

  The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension

FAQ

• Does NMN have any known side effects?

  The first human safety trial of NMN in humans was published in 2019 and showed that a single dose of up to 500mg was tolerable.

  NMN has been proven safe in high dosages up to 1.2g a day in human clinical studies. Furthermore, multiple health benefits have been demonstrated in humans as well. A study in prediabetic, postmenopausal, obese or overweight women showed that after 10 weeks of NMN supplementation, the volunteers had increased insulin sensitivity. Same study showed that NMN supplementation was able to stimulate the collagen production pathway, suggesting the compound's role in healthy aging (and appearance of skin).

  A study in elderly men over 65 showed that NMN supplementation protects against age-related muscle loss. Another study in healthy, adult volunteers of both sexes confirmed that NMN increases endurance, cardiovascular fitness and aerobic capacity in amateur runners. 

• Why should I take NMN before breakfast?

  It increases absorption.

• How much NMN should I take?

  If you're younger than 35, you can start with 250mg/day and after 1-2weeks increase to 500mg to see what feels better.If you're older than 35, start with 500mg/day, then increase to 1g to see what feels better.

• Should I take one capsule in the morning and one in the afternoon?

  No. Take your NMN in the morning to synchronize your NMN consumption with your Circardian rhythms.

• Should I break down the capsule for better absorption?

  Dr David Sinclair and our founder Dr Elena Seranova don't bother and just take the capsule. There are actually no studies showing that sublingual powder or powder intake results in better absorption than the capsule.

• What can amplify the effect of NMN supplementation?

  Along with your NMN, take one tablespoon of extra virgin olive oil in the morning. Oleic acid, one of the ingredients in olive oil, is also shown to activate the SIRTUINS, the so-called longevity genes.
  
  In addition, by supplementing with TMG (Trimethylglycine), you increase the methyl groups available in the cell (which NMN utilises). Adding TMG to your NMN supplementation is an excellent way to boost NMN efficiency and ensure balanced homocysteine levels.