How having low insulin sensitivity WILL make you gain weight, be less cognitively efficient & increase risk of dangerous chronic disease.

How can I improve it?

There are lifestyle changes such as lots of exercise & strict diet changes to having less sugary foods & refined carbs to have a good chance of increasing insulin sensitivity.
Not long ago, a remarkable new study (link down below) released has shown there could be a much easier way to increase insulin sensitivity – and NMN supplements are right at the heart of it.

The fascinating new study, published in Science, drilled down into the effects supplementing with NMN for 10-weeks had on post-menopausal women who had all been identified as overweight and pre-diabetic. Remarkably, even at a low dose of just 250mg NMN, muscle insulin sensitivity for those women was shown to be an average of 25% higher. The huge significance of this is a decline in insulin sensitivity is one of the key causes of type 2 diabetes, so the results indicate NMN could play a vital role in combating the condition understood to be the seventh leading cause of death in the United States alone.

Scientists were optimistic the human study would produce promising results for female participants as previous studies with mice have already shown how effective NMN was in increasing muscle insulin sensitivity for female mice.

The review explains, “We specifically studied post-menopausal women because NMN treatment caused greater beneficial metabolic effects in female than male mice with diet-induced diabetes.” Just how remarkable these latest results are could not have been predicted though.

Several parameters were evaluated in this study, such as “body composition, blood pressure, plasma glucose, insulin, free fatty acid, lipids, adiponectin and leptin concentrations, and both basal glucose and fatty acid kinetics, that did not change in either group after 10 weeks of treatment.”

So, what are the significant findings from this study?

First and foremost, it was interesting to get evidence of NMN supplementation boosting the plasma concentration of NMN metabolites N-methyl-2-pyridone-5-carbox-amide and N-methyl-4-pyridone-5-carboxamide. Moreover, after 10 weeks of treatment, the muscle content of NAD+ and nicotinamide did not change, but the level of NAD+ intermediates N-methyl-nicotinamide, me-thyl-2-pyridone-5-carboxamide, and N-methyl-4-pyridone-5-carboxamide increased significantly, suggesting NMN managed to increase the overall NAD+ turnover in muscle tissue. These 2 findings are important as they indicate the oral bioavailability of NMN and the fact that it does indeed affect NAD+ levels.

In addition, the study found an “increase in muscle insulin signalling and muscle insulin sensitivity in postmenopausal women with pre-diabetes who are overweight or obese. This improvement in muscle insulin sensitivity is clinically relevant and is similar to the improvement observed after ~10% weight loss…”

This human study was a “randomized, placebo-controlled, double-blind trial” to ensure the effect of NMN supplementation was evaluated as effectively as possible. Dr David Sinclair, a Harvard Geneticist looked to for his expertise in the ageing field, openly said he takes 1g of NMN daily, and many longevity enthusiasts take at least 500mg-1g of NMN per day.
As many animal studies have already shown NMN supplementation not only boosts the levels of an essential coenzyme called NAD+ but also reverses the signs of ageing, NMN has subsequently become one of the bestselling supplements on the anti-ageing market.

This unveiling of its power to increase muscle insulin sensitivity will no doubt add to the supplement’s growing popularity.

Further good news from the study is there were no adverse events reported whatsoever from the trial – indicating just how safe NMN, also found naturally in foods such as avocado and broccoli, is to take. As the Diabetes UK website reveals, one in ten people over 40 in the UK are now living with a diagnosis of type 2 diabetes – and it is predicted by 2030 this number will rise to 5.5 million.

With this latest study showing how safe and effective NMN can be in improving insulin muscle sensitivity, it may not be long before GPs are handing out NMN as the most effective way to curb the rise in patients with diabetes – and to curb the rise in those blood glucose levels.

This is why I founded NMN Bio. As a scientist, I stumbled upon NMN while studying the biology of aging, NAD metabolism and human health. The remarkable safety profile along with rapid efficiency is what fascinated me. My mission is to help as many people as possible with the merciless health problems that aging brings. And launching NMN Bio with NMN as our first and main product, helps me do just that.
I am certain about the product I’m selling, as there is robust science demonstrated in both animal studies and human trials, confirming that NMN is one of the most promising anti-aging compounds on the market. That’s the reason I personally stand behind the brand. Because as a scientist, I launched the company to operate under the principle of complete transparency.