Fisetin: Benefits, Dosage and Side Effects

Delving into the world of dietary supplements, one may stumble upon a lesser-known compound called fisetin. This naturally occurring flavonoid, found in a variety of fruits and vegetables, has been the subject of numerous scientific studies due to its potential health benefits. This blog post aims to shed light on fisetin, its relationship with dietary quercetin, and the potential health benefits that have been linked to it in early research.

Fisetin, despite its relative obscurity, plays a significant role in our diet. It's a member of the flavonoid family, much like its better-known cousin, dietary quercetin. Both of these compounds are found in a variety of fruits and vegetables, and they share many similar properties. However, fisetin has been shown to have unique benefits of its own, which we will explore in the following sections.

The potential health benefits of fisetin are vast and varied. From its antioxidant and anti-inflammatory properties to its effects on blood glucose and body mass, fisetin has shown promise in a number of areas. There's even early research suggesting that fisetin could play a role in reducing the risk of coronary heart disease. However, it's important to note that much of this research is still in its early stages, and more studies are needed to fully understand the potential of this compound.

If you're considering adding fisetin to your supplement regimen, it's crucial to understand the recommended dosage and how to supplement safely. Like any supplement, fisetin can have potential side effects, and understanding these risks is key to safe and effective supplementation. In the final section of this blog, we'll delve into the potential side effects of fisetin, backed by scientific studies, to help you make an informed decision about whether this supplement is right for you.

Understanding Fisetin and Dietary Quercetin

Fisetin, a naturally occurring flavonoid, has been gaining attention in the health and wellness sphere. Found in a variety of fruits and vegetables, it's a potent antioxidant with a myriad of potential health benefits. But what exactly is fisetin? And how does it relate to dietary quercetin, another flavonoid found in our daily diet?

Fisetin is a bioactive compound found in several fruits, most notably strawberries. It's been linked to a range of health benefits, from anti-ageing effects to potential cancer prevention. But it's not just about fisetin. Dietary quercetin, another flavonoid, plays a significant role in our health too.

Quercetin is a type of flavonoid antioxidant that's found in plant foods, including leafy greens, tomatoes, berries and broccoli. Like fisetin, it's been associated with numerous health benefits. But how do these two flavonoids interact? And what role do they play in our diet?

In this section, we'll delve into the world of fisetin and dietary quercetin, exploring their sources, benefits, and the role they play in our health. We'll also look at how they interact and the potential benefits of consuming them together. So, let's embark on this journey of understanding fisetin and dietary quercetin.

What is Fisetin?

Fisetin, a naturally occurring flavonoid, is found in a variety of fruits and vegetables. It's a plant pigment that gives fruits like strawberries their vibrant colour. But it's not just a pretty face. Fisetin is a potent antioxidant, known for its ability to neutralise harmful free radicals in the body.

This flavonoid is also a bioactive compound, meaning it interacts with our biological systems in beneficial ways. It's been studied for its potential to support brain health, improve memory, and slow down the ageing process.

But the benefits of fisetin don't stop there. It's also been linked to improved heart health and reduced inflammation. It's a powerful ally in the fight against chronic diseases, including cancer.

However, despite its many benefits, fisetin is not as well-known as other flavonoids, like quercetin. This is partly because it's not as abundant in our diet. Strawberries are the richest source of fisetin, but it's also found in smaller amounts in apples, persimmons, and onions.

In conclusion, fisetin is a powerful flavonoid with a range of health benefits. It's a testament to the power of fruits and vegetables, and a reminder of the importance of a varied, colourful diet.

The Role of Dietary Quercetin

Dietary quercetin, a flavonoid found in a variety of fruits and vegetables, plays a significant role in our health. It's a potent antioxidant, combating harmful free radicals in the body. This action helps to reduce inflammation and protect our cells from damage.

Quercetin is also known for its potential to enhance the effects of fisetin. When consumed together, these two compounds can work synergistically, amplifying their individual benefits. This is particularly beneficial for those seeking to optimise their health and wellness.

The most abundant sources of dietary quercetin include onions, apples, and berries, particularly strawberries. Incorporating these foods into your diet can help to increase your intake of this beneficial compound.

However, it's important to note that the bioavailability of dietary quercetin can be quite low. This means that even if you consume a lot of quercetin-rich foods, your body may not absorb all of it. That is the reason many choose to supplement with Quercetin. NMN Bio's Quercetin is enhanced with Vitamin C and citrus bioflavonoids to prevent it from oxidation when it is consumed orally, and to enhance bioavailability.

Despite this, dietary quercetin still offers numerous health benefits. It's a valuable addition to a balanced diet, especially when combined with fisetin. Together, they can help to support overall health and wellbeing.

Potential Health Benefits of Fisetin

Delving into the potential health benefits of Fisetin, a naturally occurring flavonoid, we uncover a myriad of promising attributes. From its potent antioxidant and anti-inflammatory properties to its potential in managing blood glucose and body mass, Fisetin is emerging as a significant player in the health and wellness sphere. Furthermore, early research and studies suggest its potential in reducing the risk of coronary heart disease, further amplifying its importance. This section will explore these benefits in detail, providing a comprehensive understanding of this powerful compound.

Antioxidant and Anti-inflammatory Properties

Fisetin, a flavonoid found in various fruits and vegetables, has been gaining attention in the scientific community for its potential health benefits. One of the most notable properties of fisetin is its antioxidant capacity. Antioxidants are crucial in combating oxidative stress, a condition linked to chronic diseases such as cancer and heart disease. Fisetin's antioxidant properties have been demonstrated in numerous studies, showing its potential in neutralising harmful free radicals in the body.

In addition to its antioxidant capabilities, fisetin also exhibits anti-inflammatory properties. Inflammation is a natural response of the body to injury or infection. However, chronic inflammation can lead to various health problems, including heart disease and cancer. Fisetin has been shown to inhibit the production of inflammatory molecules, thereby reducing inflammation in the body.

The antioxidant and anti-inflammatory properties of fisetin are intertwined. Oxidative stress can trigger inflammation, and inflammation can lead to further oxidative stress. By acting as both an antioxidant and an anti-inflammatory agent, fisetin may help break this vicious cycle. Fisetin has been shown to have neuroprotective effects for the brain, as it is a blood brain barrier permeable compound. It appears that it's anti-inflammatory effects are playing a key role in reducing neuroinflammation, something that leads to enhanced cognitive function and better sleep. That's the reason Fisetin has been included as a premium ingredient in the NAD+ Brain supplement. The NAD+ Brain proprietary blend of 12 ingredients supports focus and concentration, along with long-term benefits of slowing down the aging process in the human brain and preserving NAD+ levels.

Effects on Blood Glucose and Body Mass

Fisetin's potential health benefits extend to the regulation of blood glucose and body mass. Early research and studies have shown that this flavonoid may have a significant impact on these health parameters. In animal models, fisetin has been observed to reduce blood glucose levels, suggesting a potential role in managing diabetes.

Moreover, fisetin's influence on body mass is also noteworthy. Studies have indicated that it may inhibit the growth of fat cells, thereby potentially aiding in weight management. This could be particularly beneficial for individuals struggling with obesity or those aiming to maintain a healthy weight.

However, it's important to note that these findings are preliminary. More extensive research is needed to fully understand fisetin's effects on blood glucose and body mass in humans.

While the potential health benefits of fisetin are promising, it's crucial to approach these findings with a degree of caution. Until more definitive evidence is available, it's recommended to consult with a healthcare professional before incorporating fisetin into your routine for these purposes.

Potential in Reducing Risk of Coronary Heart Disease

The potential health benefits of fisetin extend to the cardiovascular system, particularly in the context of coronary heart disease. Early research and studies suggest that fisetin may play a role in reducing the risk of this prevalent condition.

One of the ways fisetin may achieve this is by mitigating the effects of oxidative stress, a key factor in the development of coronary heart disease. As an antioxidant, fisetin can neutralise harmful free radicals, potentially preventing damage to the heart's blood vessels.

Inflammation is another contributing factor to coronary heart disease. Fisetin's anti-inflammatory properties may help to reduce inflammation in the body, further lowering the risk of heart disease.

However, while these findings are promising, more extensive research is needed to fully understand the potential of fisetin in this area. It's important to note that fisetin should not be used as a replacement for traditional heart disease treatments, but rather as a potential supplement to a healthy lifestyle.

Early Research and Studies

Early research and studies have begun to shed light on the potential health benefits of fisetin. These preliminary investigations, although not yet definitive, are promising. They suggest that fisetin could have a significant impact on human health, particularly in the areas of inflammation, blood glucose regulation, body mass control, and coronary heart disease prevention.

One study, for instance, found that fisetin reduced inflammation in mice. This is a promising finding, as chronic inflammation is linked to a host of health problems, including heart disease and cancer. Another study found that fisetin helped regulate blood glucose levels in diabetic mice, suggesting it could potentially be used as a treatment for diabetes.

In terms of body mass, early research has shown that fisetin may help prevent weight gain. In one study, mice that were fed a high-fat diet and supplemented with fisetin gained less weight than those that were not. This suggests that fisetin could potentially be used as a weight management tool.

Finally, early studies have indicated that fisetin may reduce the risk of coronary heart disease. In one study, fisetin was found to inhibit the formation of atherosclerotic plaques, which are a major cause of heart disease. While these findings are preliminary, they suggest that fisetin could potentially play a role in heart health. In addition, studies suggest that fisetin could be beneficial for brain health and cognitive function. Interestingly, fisetin protected against cognitive decline in a human clinical study. Moreover, fisetin acts as a senolytic agent, shown to block CD38, an inflammatory enzyme correlated with aging and the presence of senescent or "zombie" cells. As fisetin is blood brain barrier permeable, it's an excellent supplement to take in order to nourish your brain and protect it from neuroinflammation, a condition associated with brain aging. Our NAD+ Brain supplement blend contains fisetin and guards your brain against oxidative stress and aging. 

Dosage and Advice for Fisetin Supplementation

Navigating the world of supplements can be a daunting task, especially when it comes to understanding the correct dosage and the best practices for safe supplementation. This is particularly true for fisetin, a potent flavonoid that has been gaining attention for its numerous health benefits. In this section, we delve into the specifics of fisetin supplementation, providing you with the recommended dosage and advice to ensure you reap the benefits of this powerful compound without compromising your health. We'll explore the science-backed guidelines, helping you to understand how much fisetin to take, when to take it, and what to consider for safe and effective supplementation. This information is crucial for anyone considering adding fisetin to their health regimen, as it provides a roadmap to maximise the benefits while minimising potential side effects.

Recommended Dosage

The recommended dosage of fisetin varies depending on the individual's health status and the specific health goal. For general health maintenance, a daily dosage of 100mg to 500mg is often suggested. However, for those seeking to leverage fisetin's potential anti-ageing benefits, a higher dosage of up to 1000mg per day may be recommended.

It's important to note that these are general guidelines and individual needs may vary. For instance, those with a higher body mass may require a larger dosage to achieve the same effects. Similarly, those with specific health conditions may need to adjust their dosage accordingly.

Furthermore, it's crucial to remember that fisetin is a supplement and not a replacement for a balanced diet and healthy lifestyle. It should be used as part of a comprehensive health strategy, not as a standalone solution.

Lastly, while fisetin is generally considered safe, it's always wise to consult with a healthcare professional before starting any new supplement regimen. They can provide personalised advice based on your unique health profile and needs.

In conclusion, while there are general guidelines for fisetin dosage, it's essential to tailor your intake to your specific needs and circumstances. Always consult with a healthcare professional to ensure you're using fisetin safely and effectively.

Advice for Safe Supplementation

When considering fisetin supplementation, it's crucial to remember that more isn't always better. While fisetin has been shown to have numerous health benefits, excessive intake can lead to unwanted side effects. Therefore, it's essential to stick to the recommended dosage.

It's also important to note that fisetin is a supplement, not a replacement for a balanced diet and healthy lifestyle. It should be used to complement these, not substitute them.

Before starting any new supplement regimen, it's always wise to consult with a healthcare professional. They can provide personalised advice based on your health history and current medications.

Remember, supplements can interact with certain medications, so it's crucial to disclose all the medications you're currently taking.

Lastly, always purchase your supplements from reputable sources. The supplement industry is not tightly regulated, and products can vary in quality.

In conclusion, while fisetin can be a beneficial addition to your health regimen, it's essential to use it safely and responsibly.

Potential Side Effects of Fisetin

While fisetin, a flavonoid found in many fruits and vegetables, is lauded for its health benefits, it's crucial to also consider its potential side effects. As with any supplement, understanding the risks associated with fisetin is key to making an informed decision about its use.

Scientific studies have been conducted to shed light on these potential side effects, providing valuable insights into the risks of fisetin consumption. These studies, while not exhaustive, offer a starting point for those considering adding fisetin to their health regimen.

However, it's important to remember that individual reactions to fisetin can vary, and what may be a side effect for one person may not be for another. Therefore, it's always recommended to consult with a healthcare professional before starting any new supplement, including fisetin.

In the following sections, we will delve deeper into the potential side effects of fisetin, the risks associated with its use, and the findings from various studies. This information aims to provide a balanced view of fisetin, allowing you to weigh its benefits against its potential risks.

Remember, knowledge is power, and understanding the potential side effects of fisetin is a crucial step towards making an informed decision about your health.

Understanding the Risks

While fisetin is generally considered safe, it's crucial to understand the potential risks associated with its consumption. The side effects of fisetin are not widely studied, and the information available is somewhat limited. However, some users have reported experiencing mild discomfort after taking fisetin supplements.

These discomforts may include stomach upset, nausea, and diarrhoea. It's also worth noting that fisetin may interact with certain medications, potentially altering their effectiveness. Therefore, individuals on medication should consult their healthcare provider before starting a fisetin regimen.

Moreover, the long-term effects of fisetin are not well-understood. While short-term use appears to be safe, more research is needed to determine the potential risks associated with long-term use. Until more comprehensive studies are conducted, it's advisable to use fisetin with caution and under the guidance of a healthcare professional.

Studies on Side Effects

While fisetin is generally considered safe, it's crucial to delve into the scientific literature to understand potential side effects better. Several studies have been conducted to assess the safety profile of fisetin, with most focusing on its effects when consumed in high doses.

One study, for instance, found that high doses of fisetin could potentially cause kidney damage in mice. However, it's important to note that the dosage used in this study was significantly higher than what a human would typically consume.

Another study conducted on human cells suggested that fisetin might interfere with certain medications, particularly those used for blood thinning. This could potentially increase the risk of bleeding in individuals taking these medications.

Yet another study indicated that fisetin might have a mild inhibitory effect on certain liver enzymes. This could potentially affect the metabolism of other drugs, leading to increased drug levels in the body.

While these studies provide valuable insights, it's important to remember that more research is needed to fully understand the potential side effects of fisetin in humans. Until then, it's advisable to consult with a healthcare professional before starting any new supplement regimen.

The Future of Fisetin in Vibrant Health

As we delve deeper into the world of natural compounds, fisetin emerges as a promising player in the pursuit of vibrant health. This flavonoid, found in various fruits and vegetables, has shown potential health benefits that could revolutionise our approach to wellness. From its antioxidant and anti-inflammatory properties to its effects on blood glucose and body mass, fisetin has demonstrated a wide range of therapeutic potentials.

The potential of fisetin in reducing the risk of coronary heart disease is particularly noteworthy. Early research and studies have shown promising results, suggesting that fisetin could be a key player in the fight against this prevalent disease. However, as with any natural compound, it's crucial to understand the recommended dosage and advice for safe supplementation. Overconsumption or misuse could lead to unwanted side effects, undermining the potential benefits of this powerful flavonoid.

Understanding the risks associated with fisetin supplementation is equally important. While studies on side effects are still in their early stages, it's crucial to approach fisetin supplementation with caution and under the guidance of a healthcare professional. This will ensure that you reap the benefits of fisetin while minimising potential risks.

In conclusion, the future of fisetin in vibrant health looks promising. As research continues to uncover the potential health benefits of this natural compound, it's clear that fisetin could play a significant role in our pursuit of optimal health. NAD+ Brain by NMN Bio contains the purest fisetin for your brain overall health and brain support. Try it out and experience fisetin's benefits today.

Researched and reviewed by Dr Elena Seranova, Ph.D.

Dr Seranova holds an M.Sc in Translational Neuroscience from the University of Sheffield, UK, and a Ph.D in Stem Cell Biology and Autophagy from the University of Birmingham, UK. She is a published author in multiple peer-reviewed journals, including Cell Reports and Developmental Cell.