L-Tyrosine: Benefits, Dosage, and Side Effects

L-Tyrosine: Benefits, Dosage, and Side Effects

L-Tyrosine: Benefits, Dosage, and Side Effects

In the realm of health and wellness, the spotlight often shines on new and promising supplements. One such supplement that has been gaining attention is L-Tyrosine, a non-essential amino acid that plays a crucial role in the production of neurotransmitters. This blog post aims to delve into the world of L-Tyrosine, exploring its benefits, dosage, and potential side effects.

L-Tyrosine is more than just a new amino acid preparation; it's a key player in our body's biochemical processes. It's involved in the production of dopamine, a neurotransmitter that regulates mood, motivation, and reward. But how does L-Tyrosine work in the body? And what role does it play in neurotransmitter production? These are some of the questions we'll be answering in the first section of this blog.

The benefits of L-Tyrosine are wide-ranging and backed by a growing body of research. From enhancing cognitive performance to aiding in depression management, L-Tyrosine has shown promising results in human studies. It's even been linked to weight loss, making it a popular choice among those looking to shed a few pounds. But what does the evidence say about these benefits? And are there other potential benefits of L-Tyrosine that we should be aware of? We'll explore these questions in the second section.

Tyrosine administration is a topic that often raises questions. What's the recommended dosage of L-Tyrosine? How should one take it? And what factors can affect the dosage? In the third section, we'll provide answers to these questions, offering a comprehensive guide on how to use this supplement effectively.

Like any supplement, L-Tyrosine comes with its own set of potential side effects. While it's generally considered safe for most people, there are certain groups who should exercise caution. In the final section, we'll discuss the common side effects of L-Tyrosine, its interactions with medications, and who should avoid its use.

Whether you're a healthy young man looking to boost your cognitive performance, a patient seeking relief from depression symptoms, or someone interested in the potential weight loss benefits of L-Tyrosine, this blog post is for you. Join us as we unravel the mysteries of this intriguing supplement, providing you with the information you need to make an informed decision about its use.

Understanding L-Tyrosine

Dive into the world of L-Tyrosine, a nonessential amino acid that plays a crucial role in the human body. This section will explore what L-Tyrosine is and how it functions within our bodies. We'll delve into the science behind its role in the production of neurotransmitters, hormones, and proteins. We'll also discuss the research and human studies conducted on tyrosine administration and its potential benefits. This new amino acid preparation has been the subject of numerous studies, particularly for its role in dopamine production. So, let's embark on this journey to understand L-Tyrosine better.

What is L-Tyrosine?

L-Tyrosine, often simply referred to as tyrosine, is an amino acid that naturally occurs in the human body. It's a fundamental building block of protein, contributing to the structure of almost all proteins within the body. This nonessential amino acid is synthesised from another amino acid, phenylalanine, which means the body can produce it without the need for dietary intake.

However, certain individuals may have lower levels of L-Tyrosine due to a hereditary condition known as phenylketonuria (PKU). In such cases, tyrosine administration through supplements can help increase its levels in the body.

Tyrosine is also present in various foods, including meat, fish, eggs, dairy products, beans, nuts, oats, and wheat. Despite being a new amino acid preparation in the world of supplements, it has been used in alternative medicine to potentially improve mental performance, alertness, and memory.

However, it's important to note that the medicinal use of L-Tyrosine has not been approved by the FDA, and it should not be used as a substitute for medication prescribed by a healthcare professional. As with any supplement, it's crucial to purchase from a reliable source to minimise the risk of contamination.

While research and human studies on L-Tyrosine are ongoing, it's clear that this amino acid plays a significant role in our bodies, contributing to protein synthesis, hormone production, and neurotransmitter function.

How does L-Tyrosine work in the body?

L-Tyrosine, a nonessential amino acid, plays a crucial role in the body's protein synthesis. It's a building block for protein, contributing to the structure of almost all proteins in the body. But its role extends beyond protein formation. It's also involved in the production of hormones by the adrenal, pituitary, and thyroid glands.

Tyrosine administration is also linked to the production of melanin, the pigment responsible for hair and skin colour. This new amino acid preparation is also found in many foods we consume, including eggs, chicken, turkey, fish, soy, cheese, yogurt, and some nuts and seeds.

Research and human studies have shown that L-Tyrosine is a precursor to the neurotransmitters epinephrine, norepinephrine, and dopamine. These neurotransmitters are vital for communication between nerve cells and play a significant role in regulating mood, alertness, and cognitive function.

In stressful situations, L-Tyrosine can help maintain the levels of these neurotransmitters, offering protection against cognitive decline and mood-related changes due to stress. This is particularly beneficial for individuals under a lot of stress or suffering from depression.

However, it's important to note that while L-Tyrosine has these potential benefits, more research is needed to fully understand its role in our bodies. It's also crucial to remember that L-Tyrosine should not be used in place of medication prescribed by your doctor.

The role of L-Tyrosine in neurotransmitter production

L-Tyrosine plays a crucial role in the production of neurotransmitters, the chemical messengers that transmit signals in the brain. It's a precursor to three significant neurotransmitters: dopamine, norepinephrine, and epinephrine. These neurotransmitters are essential for regulating mood, alertness, and stress response.

Dopamine, often referred to as the 'feel-good' neurotransmitter, is responsible for our reward and pleasure centres. It's also involved in motor control and the release of various hormones. Research has shown that tyrosine administration can influence dopamine levels, which can impact mood and cognitive function.

Norepinephrine and epinephrine, also known as adrenaline, are part of the body's stress response system. They prepare the body for 'fight or flight' during stressful situations. Tyrosine is crucial in maintaining adequate levels of these neurotransmitters, especially during periods of stress or physical exertion.

Human studies have shown that tyrosine supplementation can help replenish these neurotransmitters, offering protection against cognitive decline and mood-related changes due to stress. This makes tyrosine a potentially beneficial new amino acid preparation for those under high stress or suffering from mood disorders.

However, it's important to note that while tyrosine plays a significant role in neurotransmitter production, its effects may not be strong enough to have a substantial stress-reducing effect in most people eating a balanced diet. More research is needed to fully understand the extent of tyrosine's impact on neurotransmitter production and overall brain health. With that being said, tyrosine can pleasantly affect your mood when take in the right dosage. Our proprietary nootropic blend, the NAD+ Brain, contains 100mg of tyrosine per serving, contributing to improved cognitive state on a daily basis. 


The Benefits of L-Tyrosine

Dive into the world of L-Tyrosine, a non-essential amino acid that's been making waves in the health and wellness sphere. This protein building block, naturally occurring in our bodies and certain foods, has been linked to a range of potential benefits. From cognitive performance to depression management, L-Tyrosine is a supplement that's been garnering attention.

In the realm of cognitive performance, L-Tyrosine has been used as a possible aid in enhancing mental alertness and memory. This is particularly relevant for healthy young men, who may see an improvement in their cognitive abilities with the use of this supplement.

When it comes to depression, L-Tyrosine has been explored as a potential treatment. While research has shown that it may not be effective in treating this condition, it's still a topic of interest in the medical community.

Weight loss is another area where L-Tyrosine has been investigated. While it may not directly lead to weight loss, it could potentially aid in fat loss when used in combination with other natural substances.

Beyond these areas, L-Tyrosine has other potential benefits that are yet to be fully explored. From its role in managing conditions like premenstrual syndrome and Parkinson's disease to its potential use in treating alcoholism and cocaine addiction, the scope of L-Tyrosine's benefits is vast and intriguing.

L-Tyrosine and cognitive performance

L-Tyrosine has been linked to enhanced cognitive performance, particularly in stressful situations. Research has shown that this amino acid can help improve mental agility and memory when under stress. For instance, a study involving a cognitive flexibility test showed that participants performed better when they took an L-tyrosine supplement compared to a placebo.

Another study demonstrated that individuals working on mentally demanding tasks experienced an improvement in their working memory while taking L-tyrosine. This was particularly evident in short-term stressful situations or cognitively demanding scenarios. However, it's important to note that these results were primarily observed during periods of extreme physical stress, and may not necessarily apply to the general population experiencing mild stress from daily activities.

Furthermore, L-tyrosine has been found to enhance alertness during times of sleep deprivation. In a study involving people who were sleep-deprived due to working overnight, those who took tyrosine experienced a significant reduction in mental performance decline for about three hours compared to the control group.

While L-tyrosine doesn't necessarily make you feel less stressed, it can help maintain cognitive performance during stressful periods. Therefore, it's often marketed to alleviate the effects of stress, particularly during periods of physical stress when the body depletes its levels of catecholamines, neurotransmitters that L-tyrosine helps replenish.

In conclusion, L-tyrosine can potentially be used to improve learning and alertness while decreasing brain fog, especially during stressful situations. However, more research is needed to fully understand its effects on cognitive performance in different contexts.

L-Tyrosine's role in depression management

The role of L-tyrosine in managing depression is a topic of ongoing research. Depression, a complex disorder, affects one in six people at some point in their lives. It's believed to be linked to an imbalance of neurotransmitters in the brain, such as serotonin and dopamine. L-tyrosine, an amino acid, can increase these neurotransmitters, making it a potential remedy for depression.

However, the evidence is mixed. Some studies suggest that L-tyrosine has no antidepressant effects, while others indicate that individuals with low levels of dopamine could see significant benefits from supplementing with L-tyrosine. For instance, one study found that tyrosine provided clinically significant benefits for individuals with dopamine-deficient depression, a condition characterised by low energy and lack of motivation.

Despite these promising findings, it's important to note that the current evidence does not support supplementing with tyrosine to treat symptoms of depression. More research is needed to fully understand the role of L-tyrosine in depression management. Until then, it's not recommended to use L-tyrosine supplements for treating depression.

In conclusion, while L-tyrosine may have potential benefits for certain individuals, it's not a one-size-fits-all solution for depression. It's crucial to consult with a healthcare professional before starting any new supplement regimen.

L-Tyrosine and weight loss

While L-Tyrosine isn't a magic bullet for weight loss, it may play a supportive role in a comprehensive weight management plan. The University of Michigan Medicine states that there's no direct evidence showing L-Tyrosine promotes weight loss. However, when combined with other natural fat-burning substances like cayenne, green tea, and caffeine, it may slightly aid in fat loss among overweight adults.

A 2007 study found a modest reduction in weight of about 0.9 kg when overweight adults took tyrosine along with capsaicin, catechines, and caffeine. This suggests that L-Tyrosine could potentially contribute to weight loss when used in conjunction with other substances and a balanced diet.

On the flip side, L-Tyrosine shouldn't cause weight gain. Even if it doesn't directly lead to weight loss or influence your appetite, it may help improve appetite, cognition, and exercise tolerance among people needing to gain weight, such as those recovering from anorexia.

In conclusion, while L-Tyrosine may not directly cause weight loss, it could potentially play a supportive role in weight management, especially when combined with other natural substances and a balanced diet. However, more research is needed to fully understand the role of L-Tyrosine in weight loss.

Other potential benefits of L-Tyrosine

Beyond cognitive performance, depression management, and weight loss, L-Tyrosine has other potential benefits that are worth exploring. For instance, it plays a crucial role in the production of thyroxine, a thyroid hormone that regulates metabolism. This could be beneficial for individuals with an underactive thyroid, as it may help alleviate symptoms such as sluggish metabolism, tiredness, and sensitivity to cold.

Moreover, L-Tyrosine may be beneficial for those recovering from anorexia, as it can potentially improve appetite, cognition, and exercise tolerance. This could aid in healthy weight gain, which is crucial in the recovery process.

Interestingly, L-Tyrosine may also have a role in addiction management. Research suggests that it could be useful in managing symptoms of heroin and alcohol withdrawal. This is likely due to its ability to balance levels of catecholamines, neurotransmitters responsible for motivation, energy, and pleasure.

However, it's important to note that while these potential benefits are promising, more research is needed to fully understand the role of L-Tyrosine in these areas. As always, it's recommended to consult with a healthcare professional before starting any new supplement regimen.

In conclusion, L-Tyrosine is a versatile amino acid with a range of potential benefits. From cognitive performance to depression management, weight loss, and beyond, it's clear that this supplement could be a valuable addition to many people's wellness routines.

Dosage and Administration of L-Tyrosine

Navigating the world of supplements can be a daunting task, especially when it comes to understanding the correct dosage and administration. This section will delve into the specifics of L-Tyrosine administration, providing you with a comprehensive guide on how to take this supplement effectively. We'll explore the recommended dosage of L-Tyrosine, taking into account various factors that may influence the amount you need.

The dosage of L-Tyrosine is not a one-size-fits-all scenario. It's influenced by several factors, including your diet, overall health, and the specific condition you're treating. Therefore, it's crucial to follow your healthcare provider's instructions carefully when taking this supplement.

Understanding how to take L-Tyrosine is equally important. It's not just about the amount you take, but also the timing and method of administration. This can significantly impact the supplement's effectiveness and your body's ability to absorb and utilise it.

Lastly, we'll delve into the factors affecting L-Tyrosine dosage. These can range from your dietary protein intake to your overall health status. By understanding these factors, you can ensure you're taking the right amount of L-Tyrosine for your specific needs.

In the world of supplements, knowledge is power. By understanding the ins and outs of L-Tyrosine administration, you can make informed decisions about your health and wellbeing.

Recommended dosage of L-Tyrosine

The recommended dosage of L-Tyrosine varies depending on the individual's health status and the purpose of supplementation. For managing moodiness, depression symptoms, and boosting energy, adults have safely taken about 100 to 150 milligrams per 2.2 pounds of body weight, equivalent to about 7 grams per day for an average-sized adult.

For treating phenylketonuria (PKU), a condition where the body can't convert phenylalanine to tyrosine, the recommended dosage is usually four to six grams daily. Pregnant women with PKU may need to consume even more, up to 7.6 grams daily.

In some situations, higher doses are recommended, such as 300 milligrams per kg of body weight taken before a stressful event to help with mental performance. However, it's crucial to consult with a healthcare provider before starting any supplement regimen, including L-Tyrosine.

The dosage may also depend on the amount of protein you consume in your diet. Always follow your doctor's dosing instructions very carefully. If the condition you are treating with L-Tyrosine does not improve, or if it gets worse while using this product, it's essential to contact your healthcare provider.

Remember, L-Tyrosine is only part of a complete program of treatment that may also include a special diet. Follow the diet plan created for you by your doctor or nutrition counselor.

How to take L-Tyrosine

Taking L-Tyrosine requires a bit of strategy to ensure optimal absorption and effectiveness. It's best to take this supplement on an empty stomach, as other amino acids present in food can interfere with its absorption. This means you should avoid taking it close to meal times.

Timing is also crucial. L-Tyrosine can be stimulating, potentially reducing sleepiness. Therefore, it's recommended to take it in the morning rather than in the evening close to bedtime, especially if you're taking large amounts.

The effects of L-Tyrosine supplements can be felt within 30 to 60 minutes of administration. This timeframe, however, can vary depending on the dose you take and whether you've eaten recently. Taking this amino acid on an empty stomach generally results in faster-acting effects.

Remember, L-Tyrosine is only part of a complete treatment program that may also include a special diet. Always follow the diet plan created for you by your doctor or nutrition counsellor.

Lastly, store L-Tyrosine at room temperature, away from moisture and heat. Always keep it out of reach of children and pets to prevent accidental consumption.

Factors affecting L-Tyrosine dosage

The dosage of L-Tyrosine can be influenced by several factors. Your diet, for instance, plays a significant role. The amount of protein you consume can affect your L-Tyrosine dose. This is because tyrosine is a non-essential amino acid that the body can produce from another amino acid, phenylalanine, found in protein-rich foods.

Your health condition is another factor. If the condition you're treating with L-Tyrosine doesn't improve or worsens, it might be necessary to adjust your dosage. Always consult your doctor in such instances.

Your body weight also matters. In supplement form, L-Tyrosine is typically taken in doses of about 100 to 300 milligrams per kilogram of body weight. However, guidelines aren't clear, and it's best to work with a healthcare provider to determine what's best for you.

Interactions with certain medications can also affect your L-Tyrosine dosage. For instance, if you're taking thyroid hormone, Monoamine oxidase inhibitors (MAOIs), or Levodopa (L-dopa), you may need to adjust your L-Tyrosine dose.

Lastly, your age and overall health status can influence your L-Tyrosine dosage. It's not recommended for children without medical advice, and if you're pregnant or breastfeeding, you should seek medical advice before using L-Tyrosine.

Side Effects and Precautions

While L-Tyrosine is generally recognised as safe by the FDA and thought to be likely safe for most adults when taken for up to three months, it's crucial to be aware of potential side effects and precautions. This section will delve into the common side effects of L-Tyrosine, which may include symptoms such as nausea, fatigue, and headaches. We'll also explore how L-Tyrosine interacts with other medications, and why certain patients should avoid this supplement. Always remember to consult with a licensed healthcare professional before using any health supplement, and ensure all your healthcare providers are aware of your medical conditions and treatments. It's also important to keep all medicines out of the reach of children and only use them for the prescribed indication.

Common side effects of L-Tyrosine

L-Tyrosine, while generally safe for most adults, can cause a few side effects. These are typically mild and may include digestive issues such as nausea and heartburn. Some individuals may also experience headaches and fatigue. It's important to note that these symptoms are more likely to occur when taking large doses of the supplement over an extended period.

In some cases, high doses of up to 20 grams per day have been used safely in military studies. However, it's recommended to stick to a lower dosage of less than 1,000 milligrams per day if taking it for many weeks or months. This is to reduce the risk of side effects tied to an imbalance of amino acids.

While L-Tyrosine can increase alertness and help reduce sleepiness, it's not a stimulant drug and tends to have milder effects than substances like caffeine. However, it's possible that some people may experience an increase in hyperthyroidism symptoms.

There's also some evidence that L-Tyrosine may impact insulin signalling, which could potentially affect blood sugar management. This is particularly relevant for individuals who are obese, at high risk of type 2 diabetes, or already diagnosed with this form of diabetes.

Lastly, it's worth noting that not all side effects are known, and others may occur. If you experience any unusual symptoms while taking L-Tyrosine, it's recommended to seek medical advice.

Interactions with medications

L-Tyrosine, while beneficial, can interact with certain medications, potentially altering their effectiveness. For instance, Levodopa, a drug used for Parkinson's disease, competes with tyrosine for absorption in the small intestine. This competition could influence the efficacy of both substances. To avoid this, it's recommended to dose tyrosine two hours apart from the Levodopa dose.

Monoamine oxidase inhibitors (MAOIs), when combined with high-tyramine foods, can dangerously elevate blood pressure. Tyrosine, which breaks down to tyramine, could theoretically affect blood pressure. However, it's unclear if supplementing tyrosine would increase tyramine levels. Until more is known, it's best to avoid tyrosine supplements while on MAOIs.

Thyroid medications, used to control thyroid hormone levels, may also interact with tyrosine. Supplementing tyrosine could potentially raise hormone levels too high.

It's crucial to consult with your healthcare provider before starting any new supplement, including L-Tyrosine, especially if you're on medication. They can help you understand potential interactions and guide you on safe usage. Always remember to keep all medicines and supplements out of the reach of children and pets.

Who should avoid L-Tyrosine?

Certain individuals should exercise caution or completely avoid L-Tyrosine supplementation. Pregnant or breastfeeding individuals, for instance, should steer clear of L-Tyrosine supplements due to insufficient data on its safety. It's advisable to stick to natural food sources of tyrosine in these cases.

Patients with thyroid disorders, such as hyperthyroidism or Graves' disease, should also avoid L-Tyrosine. Supplemental tyrosine can potentially increase thyroxine levels, exacerbating these conditions.

Moreover, individuals prone to migraines might find their condition worsened by tyrosine supplementation. It's been noted that tyrosine can trigger migraine headaches, making it a risky choice for those frequently affected by this condition.

Lastly, children should not be given any herbal or health supplement, including L-Tyrosine, without medical advice. The effects of such supplements on children are not fully understood, and it's always safer to consult a healthcare provider first.

In conclusion, while L-Tyrosine can offer several health benefits, it's not suitable for everyone. Always consult with a healthcare provider before starting any new supplement regimen.

The Takeaway

L-Tyrosine, an amino acid naturally found in protein-rich foods, has been the subject of numerous studies due to its potential health benefits. As a supplement, it's often used to enhance cognitive performance, manage depression, and support weight loss. We certainly see l-tyrosine as one of the essential "brain food" components that can contribute to a better mental state, improved cognitive performance and help your mental performance on a daily basis. That's why we included the right amount of tyrosine in NAD+ Brain, the only supplement you need for your brain. It contains 12 ingredients in a proprietary formulation that aims at slightly increasing your neurotransmission baseline, enhance concentration & focus with caffenine, l-theanine and l-tyrosine, and offers neuroprotective effects to your brain at the same time. NAD+ Brain is formulated by a neuroscientist to slow down the aging process in the brain with all ingredients being blood brain barrier permeable. Amongst other benefits, the formula will contribute to the preservation of NAD+ in your brain, the master regulator of human health.  


Researched and reviewed by Dr Elena Seranova, Ph.D.

Dr Seranova holds an M.Sc in Translational Neuroscience from the University of Sheffield, UK, and a Ph.D in Stem Cell Biology and Autophagy from the University of Birmingham, UK. She is a published author in multiple peer-reviewed journals, including Cell Reports and Developmental Cell.