Rejuvenation Bundle - Look And Feel Young Again.

The best time to take care of yourself is always today. The Rejuvenation Bundle is designed to cover all the needs your cells have when it comes to energy generation, repletion of NAD+ (the master regulator of human metabolism, and key to healthy mitochondria), immunity support and healthy aging.

As we age from 25 years old, our hormone and NAD levels are significantly decreasing. This leads to inevitable health and energy decline. The result? More fatigue, longer recovery times (from both gym and night outs), less concentration and energy throughout the day. Sounds familiar? By the time we are 27, everyone has experienced these signs of aging.

The reason behind this decline in vitality is the consumption of NAD+ by multiple NADases, aka enzymes that use NAD+ to function and perform biological reactions. Certain enzymes such as PARPs and CD38, have increased activity as we age, due to their reaction to inflammation, DNA damage etc. They are competing for NAD+ with SIRTUINS, which are the genes that are suggested to correlate with healthy ageing. The latest research is the reason for the high demand in NAD+ boosting supplements, amongst longevity enthusiasts and wellness specialists. In addition to NAD+ depletion, other causes of aging such as the accummulation of old (Zombie) cells in our tissues, and the decline of our metabolic rate, all contribute to suboptimal performance in our lives when it comes to work, productivity, sports and having the capacity to be active overall.

With that in mind, we created our Rejuvenation Bundle, to fight multiple hallmarks of aging at once, and make you feel like you did in your twenties.

Our Rejuvenation Autumn Bundle combines our 4 best-selling products:

NMN - The King of Anti-Aging. Nourish your cells and boost your NAD+, the most essential component of human metabolism. Double your NAD+ levels in 2 weeks and feel your best while getting things done. The best remedy for getting rid of your need for an afternoon nap.

TMG - Support your DNA repair and give your cells what they need on a daily basis. TMG acts as a methyl donor, supplying the essential methyl groups for NMN to do it’s job more efficiently, and for processes such as DNA expression and neurotransmission.

QUERCETIN - Get rid of “Zombie” cells that cause increase in inflammation, a major driver of aging. Perhaps the most potent anti-inflammatory natural compound, proven to boost immunity

BERBERINE - Support your insulin sensitivity, boost metabolism and aid for ideal weight maintenance.

We carefully selected these products, to ensure they provide you with the best way to rejuvenate your cells, and ensure your daily schedule is not limited by your own physical and mental bottlenecks.

Our Rejuvenation Bundle aims to:

Efficiently decrease senescence cells, fight inflammation
Support a healthy cardiovascular system
Efficiently restore declining NAD+ levels, to repair energy and concentration levels
Nourish your cells and ensure your cellular maintenance is taken care of
Increase insulin sensitivity, assist with lowering blood glucose levels, and lipid metabolism
Support immunity and your body’s natural defences against seasonal viruses

NMN and Quercetin Human Clinical Trials

NMN has been proven safe in high dosages up to 1.2g a day in human clinical studies. Furthermore, multiple health benefits have been demonstrated in humans as well. A study in prediabetic, postmenopausal, obese, or overweight women showed that after 10 weeks of NMN supplementation, the volunteers had increased insulin sensitivity. Same study showed that NMN supplementation was able to stimulate the collagen production pathway, suggesting the compound's role in healthy aging (and appearance of skin). A study in elderly men over 65 showed that NMN supplementation protects against age-related muscle loss. Another study in healthy, adult volunteers of both sexes confirmed that NMN increases endurance, cardiovascular fitness and aerobic capacity in amateur runners. Moreover, a recent study in both humans and mice, demonstrated lengthening of telomeres in both humans and mice after NMN supplementation. Telomeres are the caps at the end of our chromosomes and are essential for cellular health and healthy aging. The longer they are, the more we live!
Quercetin has been proven safe in high doses up 1000mg to in human clinical studies, with a high number of studies showing no or few adverse effects and/ or toxicity. In one study, 84 patients with idiopathic hypertension and gout took 1000mg quercetin twice a day for 6 months and then 500mg twice a day for another 6 months (12 months in total). Results showed improvement of cardiac diastolic function, purine metabolism, renal function and normalization of blood pressure. Another study saw 50 women with rheumatoid arthritis who took 500mg quercetin a day for 8 weeks display lower plasma levels and lessened pain.

References
Safety study in healthy Japanese men
Efficacy study in prediabetic, post-menopausal, obese or overweight women, demonstrating increase in insulin sensitivity. Same study showed NMN is stimulating the collagen production pathway.
Efficacy study in elderly men (over 65), showing protection against age-related muscle loss
Efficacy study in healthy adults showing improved cardiovascular fitness, increased aerobic capacity and endurance in amateur runners
Efficacy study in humans and mice showing lengthening of telomeres in a dose dependent manner after 30, 45 and 60 days
Quercetin as an antiinflammatory analgesic.
Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.
WHO - Cardiovascular diseases.
Role of quercetin in cardiovascular diseases.
Therapeutic potential of quercetin as a cardiovascular agent.
Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application.