Exploring the Science of Anti-Ageing Supplements: One Month In

Exploring the Science of Anti-Ageing Supplements: One Month In


About a month ago, my parents and I embarked on a journey to explore the world of anti-aging supplements. Our quest began under the guidance of Dr. Elena Seranova, a renowned expert in translational neuroscience and stem cell biology. Dr. Seranova is the founder of NMN Bio, a longevity supplements company. In our first encounter with her, she shared her conviction that NMN (Nicotinamide Mononucleotide) holds the key to reversing the effects of aging. In this second part of our interview, Dr. Elena delves deeper into why she recommends a supplements regime that includes TMG (Trimethylglycine) and berberine, alongside NMN.

Understanding NMN

NMN, short for Nicotinamide Mononucleotide, is at the core of our anti-aging journey. Dr. Elena explained how this compound can significantly boost our NAD+ (Nicotinamide Adenine Dinucleotide) levels, a coenzyme crucial for our overall health, energy, and longevity. Sadly, NAD+ levels tend to decline as we age, contributing to the aging process. By supplementing with NMN, the goal is to enhance our cellular function and mitigate the negative effects of aging.

The Debate on NAD+ Boosters

NMN is not the only NAD+ booster out there. Other vitamin B3-derived supplements, such as nicotinamide riboside (NR) and niacin, share the spotlight. The scientific community is engaged in a spirited debate over which of these compounds is most efficient at converting into NAD+ within the body. Dr. Elena explains her preference for NMN in this regard in the first part of our interview.

Exploring TMG (Trimethylglycine)

TMG, or Trimethylglycine, is the second pillar of our supplements regimen. This compound plays a pivotal role in our metabolism by providing the essential methyl groups required for various processes, including DNA regulation and cell division. TMG aids in the efficient metabolism of the nicotinamide component of NMN, supporting the body's efforts to optimize NAD+ levels. Additionally, TMG helps regulate homocysteine levels, reducing the risk of cardiovascular disease—an especially important consideration as we age.

Unpacking Berberine

Berberine is another critical component of our anti-aging supplements regimen. This natural compound, found in various plants, has shown promise in preventing and treating inflammation-related health conditions. Berberine addresses insulin resistance, a significant factor in age-related health issues. By reducing insulin resistance and activating autophagy (the process of intracellular clearance), berberine helps curb sugar cravings and contributes to overall cellular health.

The Importance of Insulin Resistance

Dr. Elena emphasizes the vital link between insulin resistance and numerous age-related diseases, including neurodegeneration, diabetes, obesity, and cardiovascular diseases. Insulin resistance, exacerbated by excessive carbohydrate consumption, poses a significant health risk. Berberine's ability to mitigate insulin resistance makes it a valuable addition to our anti-aging arsenal.

The Role of Circadian Rhythms

Our body's circadian rhythms play a crucial role in health and aging. Dr. Elena highlights how maintaining healthy circadian rhythms is key to enhancing the benefits of NMN. Taking NMN in the morning kickstarts a spike in NAD+ levels, which regulates these rhythms. This can lead to better sleep quality, enhanced focus during the day, and improved insulin sensitivity.

Personal Experiences with the Supplements

After one month on our supplements regimen, our experiences vary. While I noticed improved concentration and energy levels, I also experienced nighttime tiredness. My sugar cravings decreased, and I lost four pounds since starting the program, primarily by reducing carbohydrate intake. My mom hasn't noticed significant changes, which she attributes to recent thyroid medication adjustments. My dad, however, experienced reduced arthritis pain and improved prostate symptoms. He's also lost weight.

Looking Ahead

While it's still early days in our anti-aging supplement journey, the initial results are promising. We're mindful of the need for further research and individualized dosage adjustments. We're cautiously optimistic about the potential benefits, and we'll continue to experiment with different dosages and cycles. The future of anti-aging science is fascinating, and we'll keep you updated on our progress.


Our quest for effective anti-aging solutions continues, guided by the expertise of Dr. Elena Seranova and a supplements regimen that includes NMN, TMG, and berberine. While we've experienced varying effects in the first month, we're committed to further exploration and optimization. Aging is a complex process, and we believe that the right combination of science, supplements, and lifestyle changes can lead to healthier and more vibrant lives. Clare who interviewed Dr Elena and gave the supplements to her family is promising to update us further on their journey.

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