SIRTUINS and NAD+ supplements for longevity

Talking us through the importance of our seven longevity genes, known medically as SIRTUINS, Dr Seranova, highlights the significance of SIRTUIN 1, explaining, “what we’ve seen is that SIRTUIN 1 is one of the first genes that would go onto the side of a double-stranded DNA break to recover it. It is heavily involved with DNA repair and a very important gene.” Ageing gene number three is next in line, Dr Seranova explains, “SIRTUIN 3 would be the other very important gene for longevity, which has a lot to do with mitochondrial health and mitochondrial function”.

We learn that these SIRTUINS “upregulate many physiological processes in order to deal with potential danger”, and that every one of our SIRTUINS “need a molecule called NAD, nicotinamide adenine dinucleotide, and without this molecule, they cannot perform their functions.”

Throughout the podcast, there’s no shying away from how much our ageing genes rely on NAD to perform at their best. As Lisa says, “The two NAD forms - NAD+ and NADH - this is the most important molecule in our body next to ATP, and ATP is our energy production”. Breaking down just how important both forms are, “NAD+, which is the oxidized form and NADH, which is the reduced form”, Dr Seranova explains how, “unfortunately we do have decreased levels of this molecule as we age.”

With NMN as the “only direct precursor of NAD” we look at how NMN is so easily absorbed as “it converts straight away to NAD” and we take an in-depth look at how this enhanced bioavailability can play such a huge role in activating SIRTUINS.