What Is 'NAD+ Brain' and How Does It Work?

NAD+ (nicotinamide adenine dinucleotide) is essential for powering your brain cells and various physiological processes within the human body. It fuels mitochondrial energy, supports DNA repair, and helps maintain clear thinking, memory, and resilience as you age. But as NAD+ levels naturally decline — especially in the brain — so does mental performance. NAD+ Brain is our proprietary nootropic blend designed to protect and optimise your brain’s NAD+ levels — the molecule your cells rely on for energy, focus, and long-term cognitive health. Unlike typical brain supplements that rely on stimulants or short-term boosts, NAD+ Brain targets the root causes of mental fatigue and NAD+ depletion. With 12 science-backed ingredients working in synergy, it helps you stay sharp, energised, and resilient, now and for the future.

Key Takeaways

• NAD+ is crucial for brain health, supporting energy production, DNA repair, and neurotransmitter functionality, with levels decreasing due to aging and various external factors.

• NAD+ Brain is a dietary supplement designed to prevent NAD+ leakage from the brain and enhance cognitive function through a blend of 12 synergistic ingredients that protect brain energy and improve mental clarity. As with other dietary supplements like citicoline and choline, it supports brain health by addressing specific needs such as memory and brain function.

• Maintaining optimal NAD+ levels is essential for preventing cognitive decline and promoting neuroprotection, making NAD+ Brain suitable for individuals looking to enhance overall brain health and performance.

Intro: The Silent Crisis — Why Your Brain’s NAD+ Is Leaking

In today’s high-stress, fast-paced world, a silent crisis is unfolding in your brain: NAD+ levels are leaking — and fast.

NAD+ is a vital coenzyme that powers mitochondrial energy, supports memory, and protects brain cells from damage. As we age, NAD+ doesn’t just decline, it gets actively degraded and drained, leading to brain fog, memory issues, and increased risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s. NAD+ boosters are one of the most promising anti-ageing breakthroughs from scientific research.

Recent studies support the claims about NAD+ and its significant impact on brain health, highlighting its role in combating aging and neurodegenerative disorders.

Yet most people only try to replenish NAD+. The smarter strategy? Protect it before it disappears. That’s exactly what our proprietary formula, NAD+ Brain, is designed to do. Rather than acting as a donor or precursor, NAD+ Brain is a 12-ingredient blend that defends your brain’s existing NAD+ levels, and fuels long-term cognitive energy and clarity. Grasping the significance of NAD+ and the reasons behind its depletion is crucial.

What Is NAD+ and Why It Matters for Brain Health

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme found in every living cell, and it’s especially important in the brain. It plays a central role in energy production, DNA repair, and cellular stress responses. In simple terms, NAD+ helps your brain cells produce energy, repair themselves, and stay resilient under pressure.

In the brain, NAD+ is essential for cognitive function. It supports neuronal activity, fuels mitochondrial energy output, and enables the synthesis of neurotransmitters like dopamine and serotonin. It also contributes to synaptic plasticity — the process that underpins learning and memory.

As NAD+ levels decline, so does your brain’s ability to function at its best. Research has linked low NAD+ levels to brain fog, memory loss, poor focus, and neurodegenerative diseases like Alzheimer’s and Parkinson’s. Studies using animal models, such as mice and C. elegans, have shown that NAD+ depletion is associated with these diseases, highlighting the need for further research in humans. Additionally, studies indicate that NADH may inhibit metastasis in breast cancer, highlighting the complexity of NAD+ interactions with cancer cell growth and DNA repair mechanisms.

Unfortunately, NAD+ levels naturally decline with age. By your 40s and 50s, levels may be half of what they were in your youth. And if you’re constantly under stress or not sleeping well, the decline accelerates. Animal studies provide valuable insights into how NAD+ precursors can influence neurogenesis and neuronal health, particularly as we age. Consider looking into anti-ageing supplements to help with maintaining these levels. Even major publications like the Financial Times have started highlighting the potential of NAD+ supplements, reflecting the growing mainstream interest in their role in supporting brain health and cellular vitality.

NAD+ Synthesis and Functions

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells, playing a pivotal role in various cellular processes. Its synthesis involves several pathways, including the de novo pathway, the Preiss-Handler pathway, and the salvage pathway. These pathways ensure that NAD+ is available to facilitate critical functions within the cell.

As a redox cofactor, NAD+ is essential for the transfer of electrons in metabolic reactions, which is crucial for the production of ATP, the primary energy currency of the cell. This energy production is vital for maintaining cellular functions and overall health. Additionally, NAD+ is involved in DNA repair, cell signaling, and the regulation of gene expression, all of which contribute to the maintenance of genome stability and cellular stress responses.

NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have gained attention as dietary supplements due to their potential health benefits. These precursors can help improve cognitive function and have shown promise in the treatment of neurological disorders, including Alzheimer’s disease and Parkinson’s disease. By supporting NAD+ levels, these supplements may enhance brain health and overall cellular function.

Why NAD+ Leaks from the Brain — And Why That’s a Problem

One of the main reasons your brain loses NAD+ over time is an enzyme called CD38. This enzyme acts like an NAD+ thief, breaking it down faster than your body can replace it. CD38 activity increases with age, inflammation, toxin exposure, and chronic stress — all of which are increasingly common in modern life.

The result? A steady drain on the molecule your brain relies on most for energy and protection.

Many people try to boost their NAD+ levels with precursors like NMN or NR, but these approaches don’t stop the root of the problem. If CD38 is still active, much of your NAD+ gets broken down before your cells can use it, even when taken in low doses.

That’s why protecting NAD+ from being degraded in the first place is crucial. It’s not just about replenishment — it’s about preservation. Supporting your brain’s natural ability to hold onto NAD+ helps prevent energy crashes, reduces oxidative stress, and improves long-term cognitive function. Free radicals generated through oxidative stress can also contribute to NAD+ degradation, further emphasising the need to protect NAD+ levels.

How NAD+ Powers Brain Energy and Performance

NAD+ is a key player in mitochondrial function — the system responsible for generating cellular energy in the form of ATP. Inside your brain cells, NAD+ is required for glycolysis, the citric acid cycle, and oxidative phosphorylation, the core processes that keep your neurons firing and your mind alert.

In addition to energy production, NAD+ also acts as a signalling molecule. It activates important enzymes like sirtuins and PARPs, which regulate DNA repair, inflammation, and cell survival. These enzymes help your brain respond to stress, heal from damage, and maintain healthy cellular communication.

CDP choline, also known as citicoline, is another compound that supports brain health and function by forming neuron cell membranes and offering neuroprotective effects. Citicoline promotes these effects, potentially enhancing cognitive functions and supporting treatments for neurological diseases.

The balance between NAD+ and its reduced form, NADH, is also vital. This NAD+/NADH ratio influences metabolic stability, redox balance, and overall cellular health — especially in energy-hungry tissues like the brain.

When NAD+ levels drop, your brain’s performance suffers. Memory becomes less sharp, concentration wanes, and mental fatigue sets in more easily. That’s why maintaining optimal NAD+ levels and protecting them from being depleted, is essential for brain health, mental clarity, and resilience against age-related cognitive decline. Enhancing NAD+ levels can improve attention, processing speed, and overall mental performance. Studies suggest that NAD+ precursors can target inflammation, apoptosis, and mitochondrial dysfunction, which are often implicated in neurological disorders.

NAD+ and Neurological Disorders

NAD+ plays a pivotal role in maintaining healthy neurological function, and its depletion has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. Research suggests that NAD+ supplementation may offer neuro-protective effects and improve cognitive function in individuals with conditions such as Alzheimer’s disease and Parkinson’s disease. These neuro-protective effects are believed to stem from NAD+’s ability to support nerve cells, reduce oxidative stress, and enhance mitochondrial function.

Clinical trials are currently underway to investigate the potential health benefits of NAD+ supplementation in individuals with neurological disorders. Early findings are promising, indicating that NAD+ may help reduce the risk of age-related neurological disorders by protecting nerve cells and supporting overall brain health.

In addition to supplementation, a balanced diet rich in dietary flavonoids, such as those found in fruits and vegetables, can support NAD+ production and improve cognitive function. These dietary sources provide essential nutrients that help maintain optimal NAD+ levels, contributing to better brain health and reduced risk of neurological diseases.

NAD+ and Mental Health Conditions

NAD+ has also been implicated in the pathophysiology of mental health conditions such as depression and bipolar disorder. Research suggests that NAD+ supplementation may offer significant protective effects against these conditions, particularly in individuals with low NAD+ levels. The anti-inflammatory properties of NAD+ are thought to play a crucial role in reducing the risk of mental health conditions by mitigating inflammation, which is often linked to mood disorders.

Clinical evidence indicates that NAD+ supplementation may serve as a useful adjunctive treatment for mental health conditions, especially for individuals who have not responded to traditional treatments. By enhancing cellular energy production and reducing oxidative stress, NAD+ helps improve overall mental well-being and cognitive function. However, there is little evidence supporting the cognitive enhancement effects of NAD+ supplementation in individuals without cognitive impairments.

However, more research is needed to fully understand the potential health benefits of NAD+ supplementation in individuals with mental health conditions. Ongoing studies aim to explore the mechanisms by which NAD+ influences mental health and to establish its efficacy and safety as a treatment option.

Introducing Our 'NAD+ Brain' Formula: A 12-Ingredient Shield

NAD+ Brain is a next-generation nootropic supplement designed not just to boost NAD+, but to protect it. Unlike standard brain supplements that focus on temporary stimulation, our proprietary 12-ingredient blood brain barrier permeable formula targets the root causes of brain aging and NAD+ depletion.

This advanced blend supports neuroplasticity, helping your brain stay adaptable, focused, and capable of processing and recalling information — even under pressure. Whether you’re tackling demanding work or want to stay mentally sharp as you age, NAD+ Brain is formulated to deliver both short-term cognitive support and long-term brain health benefits. Research from institutions like the Johns Hopkins University School of Medicine highlights the health benefits of ingredients like caffeine and citicoline in supporting brain health.

Each daily dose helps defend against age-related cognitive decline, supports brain cell energy production, and enhances focus and mental clarity. Just two capsules in the morning help optimise your brain’s energy, protect against NAD+ loss, and keep you clear-headed and sharp for years to come.

Here’s a quick overview of the 12 ingredients in NAD+ Brain and their benefits:

1. Apigenin (50mg): A dietary flavonoid with neuroprotective properties that helps reduce NAD+ breakdown.

2. Vitamin B6 (5mg): Essential for neurotransmitter production, supporting brain function and mental clarity.

3. Vitamin B5 (5mg): Crucial for energy metabolism and brain function.

4. Zinc (2mg): Supports immune function and brain health.

5. Fisetin (80mg): A potent antioxidant that helps protect brain cells from oxidative stress.

6. Phosphatidylserine (50mg): Supports cognitive function and memory.

7. Citicholine (200mg): Enhances brain energy and cognitive performance.

8. Caffeine (50mg): Boosts alertness and mental energy.

9. L-Theanine (100mg): Promotes calmness and focus, balancing the stimulating effects of caffeine.

10. Vitamin C (200mg): An antioxidant that supports brain health and immune function.

11. Inositol (200mg): Supports mental health and cognitive function.

12. L-Tyrosine (100mg): Enhances cognitive performance and stress resilience.

Each ingredient specifically blocks NAD+ depletion, protects brain energy, promotes calmness and focus, and has a protective effect for your brain food. Together, they form a comprehensive shield for your brain foods.

Block the Thieves Draining Your NAD+

Your brain’s NAD+ levels are under constant attack from hidden culprits — chronic inflammation, oxidative stress, and enzyme activity like CD38, which breaks down NAD+ as we age. Poor lifestyle habits, including processed diets, sedentary routines, and sleep deprivation, only accelerate this decline.

Managing blood pressure can also help reduce NAD+ depletion, as it is a key factor in managing symptoms of metabolic conditions.

NAD+ Brain is specifically designed to target these biological “thieves”. With powerful antioxidants like Apigenin, Vitamin C, and Fisetin, the formula helps neutralise oxidative stress and inflammation — two of the biggest drivers of NAD+ depletion.

By protecting against NAD+ breakdown, NAD+ Brain helps preserve cognitive function, mitochondrial energy, and long-term brain health, keeping your neurons resilient, energised, and sharper for longer.

Protect Brain Energy

Your brain is one of the most energy-demanding organs in your body — and without sustained cellular energy, focus, memory, and mental clarity all begin to suffer.

Lifestyle factors that affect heart disease, such as diet and habits, also impact brain health, highlighting the importance of maintaining a healthy lifestyle for overall well-being. It is important to consult a healthcare professional before taking NAD+ Brain, especially if you are on other medications, to avoid potential interactions.

NAD+ Brain is formulated to fuel your brain at the cellular level, supporting mitochondrial function and long-lasting cognitive performance. A precise dose of caffeine helps activate the central nervous system and sharpen mental alertness, while L-Theanine balances stimulation with calm, focused energy. This pairing is what keeps you sharp without the jitters — unlike your morning espresso.

Ingredients like Citicholine support acetylcholine production, improving neural communication and focus, while compounds such as Acetyl-L-Carnitine assist in mitochondrial energy production, helping your brain maintain performance under pressure. By defending NAD+ and enhancing cellular energy pathways, NAD+ Brain helps sustain peak brain function — all day, every day.

Calm and Focus

Calmness and focus are essential for cognitive performance and mental well-being. While nootropics are known for boosting brain function, essential vitamins and supportive nutrients also play a vital role.

Studies show that ingredients like Citicoline can enhance memory and attention even in healthy individuals, proving that cognitive support benefits everyone—not just those with impairments.

NAD+ Brain is formulated to promote mental clarity, calm energy, and stress resilience through a targeted blend of nootropics, adaptogens, and essential nutrients:

Key Cognitive Support Ingredients:

• Citicoline (200mg): Supports brain energy, focus, and memory.

• Phosphatidylserine (50mg): Enhances memory and cognitive function.

• L-Theanine (100mg): Promotes calm focus and helps balance the stimulating effects of caffeine.

• L-Tyrosine (100mg): Supports mental performance and stress resilience.

• Inositol (200mg): Supports mood balance and cognitive clarity.

Who Should Consider NAD+ Brain?

NAD+ Brain is designed for anyone looking to maintain and enhance brain function. Targeted users include those aged 18 and above, individuals with brain fog, those recovering from burnout, longevity enthusiasts, and students or professionals seeking cognitive enhancement. Additionally, older adults may benefit from NAD+ Brain for improving memory and brain function. NAD+ Brain is formulated to be safe for daily use, even in low doses, ensuring it provides cognitive benefits without adverse effects.

NAD+ Brain is safe for daily use and is non-stimulant, thanks to ingredients like L-theanine, which balances out the caffeine to provide smooth, non-jittery energy. Whether you’re looking to improve mental clarity, enhance cognitive function, or simply support overall brain health, NAD+ Brain offers a comprehensive solution.

How to Use It + When You’ll Feel It

For optimal results, take NAD+ Brain in the morning to align with your body’s natural rhythms. Typically, the ideal oral dose is two capsules per day, but always follow the specific instructions on the product label. Even at low doses, NAD+ Brain is designed to align with your body’s natural rhythms for optimal results.

Users can expect to feel initial effects like improved calmness and focus within 1–2 days of consistent use. Deeper potential health benefits, such as enhanced memory and cognitive function, may take 2–3 weeks to become noticeable. Consistent use of NAD+ Brain can also help improve memory, making it a valuable supplement for those looking to boost brain performance.

For even greater results, combine NAD+ Brain with NMN to leverage the synergies between these supplements. While NMN works to boost your body’s NAD+ levels, NAD+ Brain protects that NAD+ from being broken down — especially in the brain, where it’s needed most. This combination helps you replenish and retain NAD+ for optimal cognitive performance, energy, and long-term brain health.

Summary

NAD+ Brain offers a revolutionary approach to maintaining and enhancing brain health by focusing on the protection and enhancement of NAD+ levels. Unlike conventional supplements that merely replenish NAD+, NAD+ Brain proactively prevents its depletion, ensuring your brain functions at its peak. With a powerful blend of 12 scientifically-backed ingredients, NAD+ Brain addresses the root causes of NAD+ loss and supports cognitive functions, memory, and overall mental clarity. The blend of ingredients in NAD+ Brain offers neuroprotective effects, supporting cognitive functions and overall mental clarity.

NAD+ Brain also provides significant protection against cognitive decline, making it an essential addition to your wellness routine.

Incorporating NAD+ Brain into your daily wellness routine can help protect your brain from the silent crisis of NAD+ depletion, providing long-term benefits for cognitive health and performance. Whether you’re looking to enhance mental clarity, combat brain fog, or support overall brain health, NAD+ Brain is the comprehensive solution you’ve been searching for.

Frequently Asked Questions

What is NAD+ and why is it important for brain health?

NAD+ is a vital coenzyme responsible for energy metabolism, DNA repair, and neurotransmitter production within the human body, making it essential for maintaining neuronal health and optimal brain function. Its role is critical for cognitive performance, emphasising its importance for overall brain health.

How does NAD+ Brain differ from other NAD+ supplements?

NAD+ Brain stands out from other NAD+ supplements by preventing its depletion with a blend of 12 powerful ingredients aimed at enhancing brain health and cognitive function. This focused approach ensures lasting support for your brain’s vitality. NAD+ Brain, like other dietary supplements, must be generally recognized as safe to ensure its efficacy and safety for consumers.

Who should consider taking NAD+ Brain?

NAD+ Brain is recommended for individuals aged 18 and above, especially those facing brain fog, recovering from burnout, or looking to enhance cognitive performance. It offers a safe, daily option for anyone interested in boosting their mental clarity and energy. NAD+ Brain is formulated to be safe for daily use, even in low doses, ensuring it provides cognitive benefits without adverse effects.

What are the expected benefits of using NAD+ Brain?

Using NAD+ can lead to improved calmness and focus within a few days, with enhanced memory and cognitive function emerging after consistent use over a few weeks. It supports brain energy, mental clarity, and helps combat cognitive decline. The blend of ingredients in NAD+ Brain offers neuroprotective effects, supporting cognitive functions and overall mental clarity.

How should I take NAD+ Brain for optimal results?

To achieve optimal results with NAD+ Brain, take two capsules in the morning to align with your body’s natural rhythms. Additionally, consider combining it with NMN for enhanced cognitive benefits. Even at low doses, NAD+ Brain is designed to align with your body’s natural rhythms for optimal results.

Researched and reviewed by Dr Elena Seranova, Ph.D.

Dr Seranova holds a master's degree in Translational Neuroscience from the University of Sheffield, UK, and a Ph.D in Stem Cell Biology and Autophagy from the University of Birmingham, UK. She is a published author in multiple peer-reviewed journals, including Cell Reports and Developmental Cell.

LEARN MORE!

• At What Age Does NAD+ Decline and How It Impacts Your Health
• The Birth of a Breakthrough: NAD+ Brain
• Citicoline: Benefits, Dosage, and Side Effects

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